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Rifampicin/isoniazid/pyrazinamide
Combination drug / From Wikipedia, the free encyclopedia
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Rifampicin/isoniazid/pyrazinamide, also known as rifampin/isoniazid/pyrazinamide, and sold under the trade name Rifater, is a medication used to treat tuberculosis.[1] It is a fixed dose combination of rifampicin, isoniazid, and pyrazinamide.[1] It is used either by itself or along with other antituberculosis medication.[1] It is taken by mouth.[1]
Combination of | |
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Rifampicin | Rifamycin antibiotic |
Isoniazid | Anti-tuberculosis medication |
Pyrazinamide | Anti-tuberculosis medication |
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Trade names | Rifater, Trifazid, others |
AHFS/Drugs.com | FDA Professional Drug Information |
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Routes of administration | By mouth |
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![3D structure of Rifampicin/isoniazid/pyrazinamide](http://upload.wikimedia.org/wikipedia/commons/thumb/b/b0/Rifampicin_3D_1i6v.png/640px-Rifampicin_3D_1i6v.png)
Side effects are those of the underlying medications.[1] These may include poor coordination, loss of appetite, nausea, joint pain, feeling tired, and numbness.[2] Severe side effects include liver problems.[3] Use in those under the age of 15 may not be appropriate.[3] It is unclear if use in pregnancy is safe for the baby.[3]
Rifampicin/isoniazid/pyrazinamide was approved for medical use in the United States in 1994.[3] It is on the World Health Organization's List of Essential Medicines.[4]