Reversible inhibition of sperm under guidance
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Reversible inhibition of sperm under guidance (RISUG), formerly referred to as the synthetic polymer styrene maleic anhydride (SMA), is the development name of a male contraceptive injection developed at IIT Kharagpur in India by the team of Dr. Sujoy K. Guha.[citation needed]
RISUG has been patented in India, China, Bangladesh, and the United States.[1] Phase III clinical trials were underway in India, and were slowed by insufficient volunteers.[1]
Beginning in 2011, a contraceptive product based on RISUG, Vasalgel, was under development in the US by the Parsemus Foundation, who were unable to bring the product to market over the next decade.[2] In 2023, the patent for Vasalgel was acquired by NEXT Life Sciences, Inc., which plans to bring the technology to market under the name Plan A for Men.[3]