RNPEP

Aminopeptidase B is an enzyme that in humans is encoded by the RNPEP gene.^[5][6][7]

RNPEP
Identifiers
Aliases	RNPEP, AP-B, arginyl aminopeptidase, APB
External IDs	OMIM: 602675; MGI: 2384902; HomoloGene: 10628; GeneCards: RNPEP; OMA:RNPEP - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q32.1 Start 201,982,372 bp[1] End 202,006,147 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 E4 Start 135,190,450 bp[2] End 135,211,822 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon duodenum granulocyte rectum monocyte gonad right uterine tube mucosa of esophagus olfactory zone of nasal mucosa stromal cell of endometrium Top expressed in granulocyte seminal vesicula crypt of lieberkuhn of small intestine epithelium of stomach jejunum duodenum pyloric antrum molar right kidney genital tubercle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peptide binding zinc ion binding peptidase activity aminopeptidase activity metalloexopeptidase activity metalloaminopeptidase activity metallopeptidase activity hydrolase activity metal ion binding epoxide hydrolase activity Cellular component plasma membrane extracellular exosome secretory granule extracellular space extracellular region Biological process proteolysis negative regulation of blood pressure peptide catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6051 215615 Ensembl ENSG00000176393 ENSMUSG00000041926 UniProt Q9H4A4 Q8VCT3 RefSeq (mRNA) NM_020216 NM_001319182 NM_001319183 NM_001319184 NM_001159624 NM_145417 RefSeq (protein) NP_001306111 NP_001306112 NP_001306113 NP_064601 NP_001153096 NP_663392 Location (UCSC) Chr 1: 201.98 – 202.01 Mb Chr 1: 135.19 – 135.21 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000176393 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000041926 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Aurich-Costa J, Cadel S, Gouzy C, Foulon T, Cherif D, Cohen P (Apr 1998). "Assignment of the aminopeptidase B gene (RNPEP) to human chromosome 1 band q32 by in situ hybridization". Cytogenet Cell Genet. 79 (1–2): 143–4. doi:10.1159/000134703. PMID 9533033.
6. Foulon T, Cadel S, Cohen P (Oct 1999). "Aminopeptidase B (EC 3.4.11.6)". Int J Biochem Cell Biol. 31 (7): 747–50. doi:10.1016/S1357-2725(99)00021-7. PMID 10467730.
7. "Entrez Gene: RNPEP arginyl aminopeptidase (aminopeptidase B)".

Further reading

• Belhacene N, Mari B, Rossi B, Auberger P (1993). "Characterization and purification of T lymphocyte aminopeptidase B: a putative marker of T cell activation". Eur. J. Immunol. 23 (8): 1948–55. doi:10.1002/eji.1830230833. PMID 8344358. S2CID 855382.
• Gress TM, Müller-Pillasch F, Geng M, et al. (1996). "A pancreatic cancer-specific expression profile". Oncogene. 13 (8): 1819–30. PMID 8895530.
• Balogh A, Cadel S, Foulon T, et al. (1998). "Aminopeptidase B: a processing enzyme secreted and associated with the plasma membrane of rat pheochromocytoma (PC12) cells". J. Cell Sci. 111 (2): 161–9. doi:10.1242/jcs.111.2.161. PMID 9405297.
• Piesse C, Tymms M, Garrafa E, et al. (2002). "Human aminopeptidase B (rnpep) on chromosome 1q32.2: complementary DNA, genomic structure and expression". Gene. 292 (1–2): 129–40. doi:10.1016/S0378-1119(02)00650-9. PMID 12119107.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Fukasawa KM, Hirose J, Hata T, Ono Y (2006). "Aspartic acid 405 contributes to the substrate specificity of aminopeptidase B". Biochemistry. 45 (38): 11425–31. doi:10.1021/bi0604577. PMID 16981702.

External links

• The MEROPS online database for peptidases and their inhibitors: M01.014