RGS13

Regulator of G-protein signaling 13 (RGS13) is a protein that in humans is encoded by the RGS13 gene.^[5][6]

RGS13
Identifiers
Aliases	RGS13, regulator of G protein signaling 13
External IDs	OMIM: 607190; MGI: 2180585; HomoloGene: 14774; GeneCards: RGS13; OMA:RGS13 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q31.2 Start 192,636,138 bp[1] End 192,660,311 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 F|1 62.56 cM Start 144,014,392 bp[2] End 144,053,110 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in appendix jejunal mucosa lymph node gallbladder mucosa of sigmoid colon tonsil pancreatic epithelial cell mucosa of transverse colon duodenum rectum Top expressed in cumulus cell Paneth cell morula mesenteric lymph nodes jejunum epithelium of stomach duodenum medulla of thymus olfactory epithelium dermis More reference expression data BioGPS More reference expression data
Gene ontology Molecular function GTPase activator activity GTPase activity Cellular component cytoplasm cytosol nucleus plasma membrane Biological process G protein-coupled receptor signaling pathway negative regulation of signal transduction negative regulation of G protein-coupled receptor signaling pathway positive regulation of GTPase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6003 246709 Ensembl ENSG00000127074 ENSMUSG00000051079 UniProt O14921 Q8K443 RefSeq (mRNA) NM_144766 NM_002927 NM_153171 RefSeq (protein) NP_002918 NP_658912 NP_694811 Location (UCSC) Chr 1: 192.64 – 192.66 Mb Chr 1: 144.01 – 144.05 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

RGS13 is a member of R4 subfamily of the Regulator of G protein signaling (RGS) protein family, whose members have only short peptide sequences flanking the RGS domain. RGS13 suppresses the immunoglobulin E- mediated allergic responses.^[7]

RGS family members share similarity with S. cerevisiae SST2 and C. elegans egl-10 proteins, which contain a characteristic conserved RGS domain. RGS proteins accelerate GTPase activity of G protein alpha-subunits, thereby driving G protein into their inactive GDP-bound form, thus negatively regulating G protein signaling. RGS proteins have been implicated in the fine tuning of a variety of cellular events in response to G protein-coupled receptor activation. The biological function of this gene, however, is unknown. Two transcript variants encoding the same isoform exist.^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000127074 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000051079 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Johnson EN, Druey KM (May 2002). "Functional characterization of the G protein regulator RGS13". J Biol Chem. 277 (19): 16768–16774. doi:10.1074/jbc.M200751200. PMID 11875076.
6. "Entrez Gene: RGS13 regulator of G-protein signalling 13".
7. Bansal G, Xie Z, Rao S, Nocka KH, Druey KM (2008). "Suppression of immunoglobulin E-mediated allergic responses by regulator of G protein signaling 13". Nat. Immunol. 9 (1): 73–80. doi:10.1038/ni1533. PMC 2387203. PMID 18026105.

Further reading

• Gregory SG, Barlow KF, McLay KE, Kaul R, Swarbreck D, Dunham A, Scott CE, Howe KL, Woodfine K (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–321. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
• Han JI, Huang NN, Kim DU, Kehrl JH (2006). "RGS1 and RGS13 mRNA silencing in a human B lymphoma line enhances responsiveness to chemoattractants and impairs desensitization". J. Leukoc. Biol. 79 (6): 1357–1368. doi:10.1189/jlb.1105693. PMID 16565322. S2CID 39672919.
• Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Islam TC, Asplund AC, Lindvall JM, Nygren L, Liden J, Kimby E, Christensson B, Smith CI, Sander B (2003). "High level of cannabinoid receptor 1, absence of regulator of G protein signalling 13 and differential expression of Cyclin D1 in mantle cell lymphoma". Leukemia. 17 (9): 1880–1890. doi:10.1038/sj.leu.2403057. PMID 12970790. S2CID 4888825.
• Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Sierra DA, Gilbert DJ, Householder D, Grishin NV, Yu K, Ukidwe P, Barker SA, He W, Wensel TG (2002). "Evolution of the regulators of G-protein signaling multigene family in mouse and human". Genomics. 79 (2): 177–185. doi:10.1006/geno.2002.6693. PMID 11829488. S2CID 16065132.
• Druey KM, Blumer KJ, Kang VH, Kehrl JH (1996). "Inhibition of G-protein-mediated MAP kinase activation by a new mammalian gene family". Nature. 379 (6567): 742–746. Bibcode:1996Natur.379..742D. doi:10.1038/379742a0. PMID 8602223. S2CID 4362632.