Quetiapine
Atypical antipsychotic medication / From Wikipedia, the free encyclopedia
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Quetiapine, sold under the brand name Seroquel among others, is an atypical antipsychotic medication used for the treatment of schizophrenia, bipolar disorder, and major depressive disorder.[9][10] Despite being widely used as a sleep aid due to its sedating effect, the benefits of such use may not outweigh its undesirable side effects.[11] It is taken orally.[9]
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Pronunciation | /kwɪˈtaɪ.əpiːn/ kwi-TY-ə-peen |
Trade names | Seroquel, Seroquel XR, Temprolide, others |
AHFS/Drugs.com | Monograph |
MedlinePlus | a698019 |
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Routes of administration | By mouth |
Drug class | Atypical antipsychotic |
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Bioavailability | 100%[4] |
Protein binding | 83%[5] |
Metabolism | Liver via CYP3A4-catalysed sulfoxidation to its active metabolite norquetiapine (N-desalkylquetiapine)[6] |
Elimination half-life | 7 hours (parent compound); 9–12 hours (active metabolite, norquetiapine)[5][7] |
Excretion | Kidney (73%), feces (20%)[4][5][7][8] |
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ECHA InfoCard | 100.131.193 |
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Formula | C21H25N3O2S |
Molar mass | 383.51 g·mol−1 |
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Solubility in water | 3.29 mg/mL (20 °C) |
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Common side effects include sleepiness, constipation, weight gain, and dry mouth.[9] Other side effects include low blood pressure with standing, seizures, a prolonged erection, high blood sugar, tardive dyskinesia, and neuroleptic malignant syndrome.[9] In older people with dementia, its use increases the risk of death.[9] Use in the third trimester of pregnancy may result in a movement disorder in the baby for some time after birth.[9] Quetiapine is believed to work by blocking a number of receptors, including those for serotonin and dopamine.[9]
Quetiapine was developed in 1985 and approved for medical use in the United States in 1997.[9][12] It is available as a generic medication.[13] In 2021, it was the 62nd most commonly prescribed medication in the United States, with more than 10 million prescriptions.[14][15] It is on the World Health Organization's List of Essential Medicines.[16]