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Phosphinooxazolines
From Wikipedia, the free encyclopedia
Phosphinooxazolines (often abbreviated PHOX) are a class of chiral ligands used in asymmetric catalysis. Colorless solids, PHOX ligands feature a tertiary phosphine group, often diphenyl, and an oxazoline ligand in the ortho position. The oxazoline, which carries the stereogenic center, coordinates through nitrogen, the result being that PHOX ligands are P,N-chelating ligands. Most phosphine ligands used in asymmetric catalysis are diphosphines, so the PHOX ligands are distinctive. Some evidence exists that PHOX ligands are hemilabile.[1]
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