Phenprocoumon
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Phenprocoumon (marketed under the brand names Marcoumar, Marcumar and Falithrom) is a long-acting blood thinner drug to be taken by mouth, and a coumarin derivative.[2] It acts as a vitamin K antagonist and inhibits blood clotting (coagulation) by blocking synthesis of coagulation factors II, VII, IX and X. It is used for the prophylaxis and treatment of thromboembolic disorders such as heart attacks and pulmonary (lung) embolism. The most common adverse effect is bleeding. The drug interacts with a large number of other medications, including aspirin and St John's Wort. It is the standard coumarin used in Germany,[3] Austria,[4] and other European countries.[5]
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Trade names | Marcoumar, Marcumar, Falithrom |
AHFS/Drugs.com | International Drug Names |
MedlinePlus | a699003 |
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Routes of administration | By mouth |
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Pharmacokinetic data | |
Bioavailability | 100%[1] |
Protein binding | 99% |
Metabolism | Liver (CYP2C9, CYP3A4) |
Metabolites | Hydroxyl derivatives, glucuronides |
Elimination half-life | 6–7 days |
Excretion | Kidney |
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ECHA InfoCard | 100.006.464 |
Chemical and physical data | |
Formula | C18H16O3 |
Molar mass | 280.323 g·mol−1 |
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Melting point | 177–181 °C (351–358 °F) |
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