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Phenazocine
Opioid analgesic / From Wikipedia, the free encyclopedia
Phenazocine (brand names Prinadol, Narphen) is an opioid analgesic drug, which is related to pentazocine and has a similar profile of effects.[2]
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Other names | Fenazocina, Phenazocinum, DEA No. 9715 |
Routes of administration | Oral |
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ECHA InfoCard | 100.004.397 ![]() |
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Formula | C22H27NO |
Molar mass | 321.464 g·mol−1 |
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Effects of phenazocine include analgesia and euphoria, also may include dysphoria and hallucinations at high doses, most likely due to action at κ-opioid and σ receptors.[3] Phenazocine appears to be a much stronger analgesic with fewer side effects than pentazocine, probably due to a more favorable μ/κ binding ratio. Phenazocine is a much more potent analgesic than pentazocine and other drugs in the benzomorphan series, most probably due to the presence of an N-phenethyl substitution, which is known to boost μ-opioid activity in many classes of opioid analgesics.[4] Also, it does not cause spasm of the sphincter of Oddi, making it more suitable than morphine for the treatment of biliary or pancreatic pain.[5]
Regarding the two enantiomers of phenazocine, (R)-phenazocine[clarification needed] has twenty times the potency of morphine as an analgesic,[6] while (S)-phenazocine has about four times the potency of morphine.[7][full citation needed]