PHF21A

PHD finger protein 21A is a protein that in humans is encoded by the PHF21A gene.^[5][6][7]

PHF21A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2PUY, 2YQL
Identifiers
Aliases	PHF21A, BHC80, BM-006, PHD finger protein 21A, NEDMS, IDDBCS
External IDs	OMIM: 608325; MGI: 2384756; HomoloGene: 9597; GeneCards: PHF21A; OMA:PHF21A - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p11.2 Start 45,929,319 bp[1] End 46,121,454 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 E1 Start 92,093,117 bp[2] End 92,364,666 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tendon of biceps brachii blood epithelium of colon ganglionic eminence monocyte buccal mucosa cell sural nerve granulocyte ventricular zone Achilles tendon Top expressed in genital tubercle tail of embryo Rostral migratory stream spermatocyte ventricular zone medulla of thymus granulocyte aortic valve ascending aorta saccule More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding histone binding RNA polymerase II transcription regulatory region sequence-specific DNA binding chromatin binding transcription coregulator activity protein binding metal ion binding histone deacetylase activity Cellular component histone deacetylase complex DNA repair complex nucleus nucleoplasm Biological process blood coagulation negative regulation of transcription by RNA polymerase II transcription, DNA-templated histone deacetylation regulation of transcription, DNA-templated chromatin organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51317 192285 Ensembl ENSG00000135365 ENSMUSG00000058318 UniProt Q96BD5 Q6ZPK0 RefSeq (mRNA) NM_001101802 NM_016621 NM_001352025 NM_001352026 NM_001352027 NM_001352028 NM_001352029 NM_001352030 NM_001352031 NM_001352032 NM_001109690 NM_001109691 NM_138755 NM_001346704 NM_001362829 NM_001362830 NM_001362831 NM_001362832 NM_001362833 RefSeq (protein) NP_001095272 NP_057705 NP_001338954 NP_001338955 NP_001338956 NP_001338957 NP_001338958 NP_001338959 NP_001338960 NP_001338961 NP_001103160 NP_001103161 NP_001333633 NP_620094 NP_001349758 NP_001349759 NP_001349760 NP_001349761 NP_001349762 Location (UCSC) Chr 11: 45.93 – 46.12 Mb Chr 2: 92.09 – 92.36 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

BHC80 is a component of a BRAF35 (MIM 605535)/histone deacetylase (HDAC; see MIM 601241) complex (BHC) that mediates repression of neuron-specific genes through the cis-regulatory element known as repressor element-1 (RE1) or neural restrictive silencer (NRS) (Hakimi et al., 2002).[supplied by OMIM]^[7]

Interactions

PHF21A has been shown to interact with:

• HDAC1,^[6][8]
• HMG20B,^[6][8]
• Histone deacetylase 2,^[6][8][9] and
• RCOR1.^[6][8]

References

1. GRCh38: Ensembl release 89: ENSG00000135365 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000058318 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nagase T, Kikuno R, Hattori A, Kondo Y, Okumura K, Ohara O (2000). "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (6): 347–55. doi:10.1093/dnares/7.6.347. PMID 11214970.
6. Hakimi MA, Bochar DA, Chenoweth J, Lane WS, Mandel G, Shiekhattar R (May 2002). "A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes". Proc. Natl. Acad. Sci. U.S.A. 99 (11): 7420–5. Bibcode:2002PNAS...99.7420H. doi:10.1073/pnas.112008599. PMC 124246. PMID 12032298.
7. "Entrez Gene: PHF21A PHD finger protein 21A".
8. Iwase S, Januma A, Miyamoto K, Shono N, Honda A, Yanagisawa J, Baba T (Sep 2004). "Characterization of BHC80 in BRAF-HDAC complex, involved in neuron-specific gene repression". Biochem. Biophys. Res. Commun. 322 (2): 601–8. doi:10.1016/j.bbrc.2004.07.163. PMID 15325272.
9. Hakimi MA, Dong Y, Lane WS, Speicher DW, Shiekhattar R (Feb 2003). "A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes". J. Biol. Chem. 278 (9): 7234–9. doi:10.1074/jbc.M208992200. PMID 12493763.

Further reading

• Shi YJ, Matson C, Lan F, Iwase S, Baba T, Shi Y (2005). "Regulation of LSD1 histone demethylase activity by its associated factors". Mol. Cell. 19 (6): 857–64. doi:10.1016/j.molcel.2005.08.027. PMID 16140033.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Hailesellasse Sene K, Porter CJ, Palidwor G, Perez-Iratxeta C, Muro EM, Campbell PA, Rudnicki MA, Andrade-Navarro MA (2007). "Gene function in early mouse embryonic stem cell differentiation". BMC Genomics. 8: 85. doi:10.1186/1471-2164-8-85. PMC 1851713. PMID 17394647.

External links

• PHF21A+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.