PELP-1
Mammalian protein found in Homo sapiens / From Wikipedia, the free encyclopedia
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Proline-, glutamic acid- and leucine-rich protein 1 (PELP1) also known as modulator of non-genomic activity of estrogen receptor (MNAR) and transcription factor HMX3 is a protein that in humans is encoded by the PELP1 gene.[5] is a transcriptional corepressor for nuclear receptors such as glucocorticoid receptors[6] and a coactivator for estrogen receptors.[7]
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Aliases | PELP1, MNAR, P160, proline, glutamate and leucine rich protein 1 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 609455; MGI: 1922523; HomoloGene: 8664; GeneCards: PELP1; OMA:PELP1 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Proline-, glutamic acid-, and leucine-rich protein 1 (PELP1) is transcription coregulator and modulates functions of several hormonal receptors and transcription factors.[8][9] PELP1 plays essential roles in hormonal signaling, cell cycle progression, and ribosomal biogenesis.[10][11] PELP1 expression is upregulated in several cancers; its deregulation contributes to hormonal therapy resistance and metastasis; therefore, PELP1 represents a novel therapeutic target for many cancers.[12][13]