PDPNFrom Wikipedia, the free encyclopedia Podoplanin is a protein that in humans is encoded by the PDPN gene.[5][6][7] Quick Facts Available structures, PDB ...PDPNAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3WSR, 4YO0IdentifiersAliasesPDPN, AGGRUS, GP36, GP40, Gp38, HT1A-1, OTS8, PA2.26, T1A, T1A-2, T1A2, TI1A, podoplanin, D2-40External IDsOMIM: 608863; MGI: 103098; HomoloGene: 4729; GeneCards: PDPN; OMA:PDPN - orthologsGene location (Human)Chr.Chromosome 1 (human)[1]Band1p36.21Start13,583,465 bp[1]End13,617,957 bp[1]Gene location (Mouse)Chr.Chromosome 4 (mouse)[2]Band4|4 E1Start142,994,001 bp[2]End143,026,134 bp[2]RNA expression patternBgeeHumanMouse (ortholog)Top expressed intibiagonadcartilage tissueventricular zonegerminal epitheliumretinal pigment epitheliumsecondary oocyteganglionic eminencegallbladdergastric mucosaTop expressed inyolk saclungprimary oocytezygoteblastocystventricular zoneurinary bladdersecondary oocyteovarylensMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular function folic acid transmembrane transporter activity water channel activity amino acid transmembrane transporter activity water transmembrane transporter activity signaling receptor binding protein binding chaperone binding chemokine binding Cellular component integral component of membrane integral component of plasma membrane plasma membrane membrane tetraspanin-enriched microdomain lamellipodium membrane cytoplasmic vesicle filopodium membrane microvillus membrane ruffle membrane cell projection leading edge of lamellipodium cytoplasm cytosol basolateral plasma membrane apical plasma membrane cell junction membrane raft ruffle lamellipodium filopodium Biological process folic acid transport water transport platelet activation multicellular organism development regulation of cell shape amino acid transport positive regulation of epithelial to mesenchymal transition positive regulation of cell migration Rho protein signal transduction wound healing, spreading of cells positive regulation of extracellular matrix disassembly regulation of lamellipodium morphogenesis cell morphogenesis lymphangiogenesis negative regulation of cell population proliferation lung development negative regulation of apoptotic process lymph node development lymphatic endothelial cell fate commitment actin-mediated cell contraction regulation of substrate adhesion-dependent cell spreading positive regulation of platelet aggregation regulation of myofibroblast contraction amino acid transmembrane transport Sources:Amigo / QuickGOOrthologsSpeciesHumanMouseEntrez1063014726EnsemblENSG00000162493ENSMUSG00000028583UniProtQ86YL7Q62011RefSeq (mRNA)NM_001006624NM_001006625NM_006474NM_198389NM_001385053NM_013317NM_001290822NM_010329RefSeq (protein)NP_001006625NP_001006626NP_006465NP_938203NP_001277751NP_034459Location (UCSC)Chr 1: 13.58 – 13.62 MbChr 4: 142.99 – 143.03 MbPubMed search[3][4]WikidataView/Edit HumanView/Edit MouseClose
Podoplanin is a protein that in humans is encoded by the PDPN gene.[5][6][7] Quick Facts Available structures, PDB ...PDPNAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3WSR, 4YO0IdentifiersAliasesPDPN, AGGRUS, GP36, GP40, Gp38, HT1A-1, OTS8, PA2.26, T1A, T1A-2, T1A2, TI1A, podoplanin, D2-40External IDsOMIM: 608863; MGI: 103098; HomoloGene: 4729; GeneCards: PDPN; OMA:PDPN - orthologsGene location (Human)Chr.Chromosome 1 (human)[1]Band1p36.21Start13,583,465 bp[1]End13,617,957 bp[1]Gene location (Mouse)Chr.Chromosome 4 (mouse)[2]Band4|4 E1Start142,994,001 bp[2]End143,026,134 bp[2]RNA expression patternBgeeHumanMouse (ortholog)Top expressed intibiagonadcartilage tissueventricular zonegerminal epitheliumretinal pigment epitheliumsecondary oocyteganglionic eminencegallbladdergastric mucosaTop expressed inyolk saclungprimary oocytezygoteblastocystventricular zoneurinary bladdersecondary oocyteovarylensMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular function folic acid transmembrane transporter activity water channel activity amino acid transmembrane transporter activity water transmembrane transporter activity signaling receptor binding protein binding chaperone binding chemokine binding Cellular component integral component of membrane integral component of plasma membrane plasma membrane membrane tetraspanin-enriched microdomain lamellipodium membrane cytoplasmic vesicle filopodium membrane microvillus membrane ruffle membrane cell projection leading edge of lamellipodium cytoplasm cytosol basolateral plasma membrane apical plasma membrane cell junction membrane raft ruffle lamellipodium filopodium Biological process folic acid transport water transport platelet activation multicellular organism development regulation of cell shape amino acid transport positive regulation of epithelial to mesenchymal transition positive regulation of cell migration Rho protein signal transduction wound healing, spreading of cells positive regulation of extracellular matrix disassembly regulation of lamellipodium morphogenesis cell morphogenesis lymphangiogenesis negative regulation of cell population proliferation lung development negative regulation of apoptotic process lymph node development lymphatic endothelial cell fate commitment actin-mediated cell contraction regulation of substrate adhesion-dependent cell spreading positive regulation of platelet aggregation regulation of myofibroblast contraction amino acid transmembrane transport Sources:Amigo / QuickGOOrthologsSpeciesHumanMouseEntrez1063014726EnsemblENSG00000162493ENSMUSG00000028583UniProtQ86YL7Q62011RefSeq (mRNA)NM_001006624NM_001006625NM_006474NM_198389NM_001385053NM_013317NM_001290822NM_010329RefSeq (protein)NP_001006625NP_001006626NP_006465NP_938203NP_001277751NP_034459Location (UCSC)Chr 1: 13.58 – 13.62 MbChr 4: 142.99 – 143.03 MbPubMed search[3][4]WikidataView/Edit HumanView/Edit MouseClose