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p300-CBP coactivator family
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The p300-CBP coactivator family in humans is composed of two closely related transcriptional co-activating proteins (or coactivators):
- p300 (also called EP300 or E1A binding protein p300)
- CBP (also known as CREB-binding protein or CREBBP)
Quick Facts E1A binding protein p300, Identifiers ...
E1A binding protein p300 | |||||||
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![]() Crystallographic structure of the histone acetyltransferase domain of EP300 (rainbow colored, N-terminus = blue, C-terminus = red) complexed with the inhibitor lysine-CoA (space-filling model, carbon = white, oxygen = red, nitrogen = blue, phosphorus = orange).[1] | |||||||
Identifiers | |||||||
Symbol | EP300 | ||||||
Alt. symbols | p300 | ||||||
NCBI gene | 2033 | ||||||
HGNC | 3373 | ||||||
OMIM | 602700 | ||||||
PDB | 3biy | ||||||
RefSeq | NM_001429 | ||||||
UniProt | Q09472 | ||||||
Other data | |||||||
EC number | 2.3.1.48 | ||||||
Locus | Chr. 22 q13.2 | ||||||
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Quick Facts CREB binding protein (CBP), Identifiers ...
CREB binding protein (CBP) | |||||||
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Identifiers | |||||||
Symbol | CREBBP | ||||||
Alt. symbols | CBP, RSTS | ||||||
NCBI gene | 1387 | ||||||
HGNC | 2348 | ||||||
OMIM | 600140 | ||||||
PDB | 3dwy | ||||||
RefSeq | NM_004380 | ||||||
UniProt | Q92793 | ||||||
Other data | |||||||
EC number | 2.3.1.48 | ||||||
Locus | Chr. 16 p13.3 | ||||||
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Both p300 and CBP interact with numerous transcription factors and act to increase the expression of their target genes.[2][3]