OR11H6

Olfactory receptor 11H6 is a protein that in humans is encoded by the OR11H6 gene.^[5]

OR11H6
Identifiers
Aliases	OR11H6, olfactory receptor family 11 subfamily H member 6
External IDs	MGI: 3030579; HomoloGene: 27116; GeneCards: OR11H6; OMA:OR11H6 - orthologs
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q11.2 Start 20,223,710 bp[1] End 20,224,702 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 C1 Start 50,876,845 bp[2] End 50,881,342 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve right auricle Top expressed in respiratory epithelium nasal epithelium olfactory epithelium proximal tubule olfactory bulb lung More reference expression data BioGPS More reference expression data
Gene ontology Molecular function olfactory receptor activity signal transducer activity G protein-coupled receptor activity Cellular component integral component of membrane plasma membrane membrane Biological process sensory perception of smell detection of chemical stimulus involved in sensory perception of smell signal transduction response to stimulus G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 122748 258296 Ensembl ENSG00000176219 ENSMUSG00000050028 UniProt Q8NGC7 Q7TRL9 RefSeq (mRNA) NM_001004480 NM_146299 RefSeq (protein) NP_001004480 NP_666411 Location (UCSC) Chr 14: 20.22 – 20.22 Mb Chr 14: 50.88 – 50.88 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.^[5]

Ligands

• Isovaleric acid^[6]

See also

• Olfactory receptor

References

1. GRCh38: Ensembl release 89: ENSG00000176219 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000050028 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: OR11H6 olfactory receptor, family 11, subfamily H, member 6".
6. Menashe I, Abaffy T, Hasin Y, Goshen S, Yahalom V, Luetje CW, Lancet D (October 2007). "Genetic elucidation of human hyperosmia to isovaleric acid". PLOS Biology. 5 (11): e284. doi:10.1371/journal.pbio.0050284. PMC 2043052. PMID 17973576.

Further reading

• Malnic B, Godfrey PA, Buck LB (February 2004). "The human olfactory receptor gene family". Proceedings of the National Academy of Sciences of the United States of America. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.

External links

• OR11H6+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.