Non-heme iron protein
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In biochemistry, non-heme iron proteins describe families of enzymes that utilize iron at the active site but lack heme cofactors. Iron-sulfur proteins, including those that are enzymes, are not included in this definition.
Some non-heme iron proteins contain one Fe at their active sites, others have pairs of Fe centers:
- Many mono-Fe proteins are alpha-ketoglutarate-dependent hydroxylases. Major examples are the lipoxygenases, isopenicillin N synthase, protocatechuate 3,4-dioxygenase, deacetoxycephalosporin-C synthase,[1] and aromatic amino acid hydroxylases.[2]
- Major diiron enzymes include hemerythrin, some ribonucleotide reductases,[3] some methane monooxygenases, purple acid phosphatases, and ferritin.[4][5]