![cover image](https://wikiwandv2-19431.kxcdn.com/_next/image?url=https://upload.wikimedia.org/wikipedia/commons/thumb/0/08/Nimbin.svg/640px-Nimbin.svg.png&w=640&q=50)
Nimbin (chemical)
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Nimbin is a triterpenoid isolated from Neem. Nimbin is thought to be responsible for much of the biological activities of neem oil, and is reported to have anti-inflammatory, antipyretic, fungicidal, antihistamine and antiseptic properties.[2]
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Preferred IUPAC name
Methyl (2R,3aR,4aS,5R,5aR,6R,9aR,10S,10aR)-5-(acetyloxy)-2-(furan-3-yl)-10-(2-methoxy-2-oxoethyl)-1,6,9a,10a-tetramethyl-9-oxo-3,3a,4a,5,5a,6,9,9a,10,10a-decahydro-2H-cyclopenta[b]naphtho[2,3-d]furan-6-carboxylate | |
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3D model (JSmol) |
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ChEBI | |
ChemSpider | |
ECHA InfoCard | 100.106.899 ![]() |
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Properties | |
C30H36O9 | |
Molar mass | 540.609 g·mol−1 |
Density | 1.309 mg/m³ |
Melting point | 205 °C (401 °F; 478 K)[1] |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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![Thumb image](http://upload.wikimedia.org/wikipedia/commons/thumb/8/80/Nimbin_analog_N2.jpg/220px-Nimbin_analog_N2.jpg)
Nimbin is a molecule from the Neem tree found in multiple Asian countries such as China, Thailand, and India. Nimbin is part of the chemical family of limonoids and triterpenoids. Nimbin was first extracted in 1942 from the neem seed (Azadirachta indica in Latin) by Siddiqi et al. Its molecular formula was established by mass-spectrometry along with salannin, a compound whose chemical formula and properties are very close to Nimbin's. Nimbin can be extracted from different parts of the Neem tree with a solvent or supercritical carbon dioxide.[3][4] Nimbin is used for different purposes because it has multiple properties such as insecticide,[5][6] antiviral, antimicrobial,[7] anti-inflammatory,[8] and anti-fungal.[9] At first, it was commonly used in Indian and Chinese traditional medicine. For example, it can be used to treat skin conditions like eczema and psoriasis. Studies have also shown that it can be used to treat diseases caused by viruses such as the SARS COV-2[10][11] or the Dengue Virus.[12][13] However, that hasn't been demonstrated in humans and only in laboratory settings. It was a derivative of Nimbin (named N2) that was used in laboratories for the dengue virus and other uses like antimicrobial. Nimbin is relatively hydrophobic,[14] and there has been a study to make it more hydrophilic with an inclusion complex which can be helpful to enable its direct use.
![Thumb image](http://upload.wikimedia.org/wikipedia/commons/thumb/6/63/A_Neem_tree_%28Azadirachta_indica%29_at_IG_Zoo_Park.jpg/640px-A_Neem_tree_%28Azadirachta_indica%29_at_IG_Zoo_Park.jpg)