NPLOC4

Nuclear protein localization protein 4 homolog is a protein that in humans is encoded by the NPLOC4 gene.^[5][6][7]

NPLOC4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2PJH
Identifiers
Aliases	NPLOC4, NPL4, NPL4 homolog, ubiquitin recognition factor
External IDs	OMIM: 606590; MGI: 2679787; HomoloGene: 5403; GeneCards: NPLOC4; OMA:NPLOC4 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q25.3 Start 81,556,887 bp[1] End 81,648,465 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 E2 Start 120,271,196 bp[2] End 120,328,534 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastrocnemius muscle apex of heart muscle of thigh stromal cell of endometrium right testis right coronary artery islet of Langerhans left testis left ventricle right adrenal gland Top expressed in spermatocyte muscle of thigh cumulus cell interventricular septum ascending aorta aortic valve spermatid supraoptic nucleus seminiferous tubule lip More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ubiquitin binding protein binding metal ion binding ubiquitin protein ligase binding Cellular component cytoplasm cytosol nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum nucleus UFD1-NPL4 complex nucleoplasm VCP-NPL4-UFD1 AAA ATPase complex Biological process error-free translesion synthesis retrograde protein transport, ER to cytosol Golgi organization ubiquitin-dependent ERAD pathway proteasome-mediated ubiquitin-dependent protein catabolic process negative regulation of type I interferon production negative regulation of RIG-I signaling pathway ubiquitin-dependent protein catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55666 217365 Ensembl ENSG00000182446 ENSMUSG00000039703 UniProt Q8TAT6 P60670 RefSeq (mRNA) NM_017921 NM_001369698 NM_001195023 NM_199469 RefSeq (protein) NP_060391 NP_001356627 NP_060391.2 NP_001181952 NP_955763 Location (UCSC) Chr 17: 81.56 – 81.65 Mb Chr 11: 120.27 – 120.33 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

NPLOC4 has been shown to interact with UFD1L.^[5][8]

References

1. GRCh38: Ensembl release 89: ENSG00000182446 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000039703 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Botta A, Tandoi C, Fini G, Calabrese G, Dallapiccola B, Novelli G (Sep 2001). "Cloning and characterization of the gene encoding human NPL4, a protein interacting with the ubiquitin fusion-degradation protein (UFD1L)". Gene. 275 (1): 39–46. doi:10.1016/S0378-1119(01)00649-7. PMID 11574150.
6. Meyer HH, Shorter JG, Seemann J, Pappin D, Warren G (Jun 2000). "A complex of mammalian Ufd1 and Npl4 links the AAA-ATPase, p97, to ubiquitin and nuclear transport pathways". EMBO J. 19 (10): 2181–92. doi:10.1093/emboj/19.10.2181. PMC 384367. PMID 10811609.
7. "Entrez Gene: NPLOC4 nuclear protein localization 4 homolog (S. cerevisiae)".
8. Lass A, McConnell E, Fleck K, Palamarchuk A, Wójcik C (Aug 2008). "Analysis of Npl4 deletion mutants in mammalian cells unravels new Ufd1-interacting motifs and suggests a regulatory role of Npl4 in ERAD". Exp. Cell Res. 314 (14): 2715–23. doi:10.1016/j.yexcr.2008.06.008. PMID 18586029.

Further reading

• McConnell E, Lass A, Wójcik C (2007). "Ufd1-Npl4 is a negative regulator of cholera toxin retrotranslocation". Biochem. Biophys. Res. Commun. 355 (4): 1087–90. doi:10.1016/j.bbrc.2007.02.077. PMID 17331469.
• Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
• Nagase T, Kikuno R, Ishikawa K, Hirosawa M, Ohara O (2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (2): 143–50. doi:10.1093/dnares/7.2.143. PMID 10819331.