NFE2

Transcription factor NF-E2 45 kDa subunit is a protein that in humans is encoded by the NFE2 gene.^[5][6]

NFE2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2KZ5
Identifiers
Aliases	NFE2, NF-E2, p45, nuclear factor, erythroid 2
External IDs	OMIM: 601490; MGI: 97308; HomoloGene: 4491; GeneCards: NFE2; OMA:NFE2 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q13.13 Start 54,292,111 bp[1] End 54,301,015 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15 F3|15 58.62 cM Start 103,156,639 bp[2] End 103,166,830 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in blood monocyte granulocyte trabecular bone bone marrow bone marrow cells spleen testicle right lung upper lobe of left lung Top expressed in granulocyte fetal liver hematopoietic progenitor cell tibiofemoral joint blood spleen human fetus yolk sac embryo bone marrow body of femur More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein N-terminus binding transcription coactivator activity transcription cis-regulatory region binding protein binding WW domain binding DNA-binding transcription factor activity sequence-specific DNA binding DNA binding cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component cytoplasm PML body nucleus nucleoplasm protein-DNA complex Biological process hemostasis regulation of transcription, DNA-templated blood coagulation blood circulation transcription, DNA-templated multicellular organism development positive regulation of transcription, DNA-templated nucleosome disassembly regulation of transcription by RNA polymerase II regulation of megakaryocyte differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4778 18022 Ensembl ENSG00000123405 ENSMUSG00000058794 UniProt Q16621 Q07279 RefSeq (mRNA) NM_001136023 NM_001261461 NM_006163 NM_001400365 NM_001400372 NM_001400373 NM_008685 NM_001302338 NM_001302339 NM_001302340 NM_001302341 NM_001302343 NM_001400376 RefSeq (protein) NP_001129495 NP_001248390 NP_006154 NP_001289267 NP_001289268 NP_001289269 NP_001289270 NP_001289272 NP_032711 NP_001387305 Location (UCSC) Chr 12: 54.29 – 54.3 Mb Chr 15: 103.16 – 103.17 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

It is involved in megakaryocyte production.^[7]

Interactions

NFE2 has been shown to interact with CREB-binding protein.^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000123405 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000058794 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ney PA, Andrews NC, Jane SM, Safer B, Purucker ME, Weremowicz S, Morton CC, Goff SC, Orkin SH, Nienhuis AW (Sep 1993). "Purification of the human NF-E2 complex: cDNA cloning of the hematopoietic cell-specific subunit and evidence for an associated partner". Mol Cell Biol. 13 (9): 5604–12. doi:10.1128/mcb.13.9.5604. PMC 360284. PMID 8355703.
6. "Entrez Gene: NFE2 nuclear factor (erythroid-derived 2), 45kDa".
7. Gasiorek JJ, Blank V (2015). "Regulation and function of the NFE2 transcription factor in hematopoietic and non-hematopoietic cells". Cellular and Molecular Life Sciences. 72 (12): 2323–2335. doi:10.1007/s00018-015-1866-6. PMC 11114048. PMID 25721735. S2CID 18020988.
8. Hung HL, Kim AY, Hong W, Rakowski C, Blobel GA (Apr 2001). "Stimulation of NF-E2 DNA binding by CREB-binding protein (CBP)-mediated acetylation". J. Biol. Chem. 276 (14): 10715–21. doi:10.1074/jbc.M007846200. PMID 11154691.

Further reading

• Strauss EC, Andrews NC, Higgs DR, Orkin SH (1992). "In vivo footprinting of the human alpha-globin locus upstream regulatory element by guanine and adenine ligation-mediated polymerase chain reaction". Mol. Cell. Biol. 12 (5): 2135–42. doi:10.1128/MCB.12.5.2135. PMC 364385. PMID 1569944.
• Pischedda C, Cocco S, Melis A, Marini MG, Kan YW, Cao A, Moi P (1995). "Isolation of a differentially regulated splicing isoform of human NF-E2". Proc. Natl. Acad. Sci. U.S.A. 92 (8): 3511–5. Bibcode:1995PNAS...92.3511P. doi:10.1073/pnas.92.8.3511. PMC 42197. PMID 7724591.
• Shivdasani RA, Rosenblatt MF, Zucker-Franklin D, Jackson CW, Hunt P, Saris CJ, Orkin SH (1995). "Transcription factor NF-E2 is required for platelet formation independent of the actions of thrombopoietin/MGDF in megakaryocyte development". Cell. 81 (5): 695–704. doi:10.1016/0092-8674(95)90531-6. PMID 7774011. S2CID 14195541.
• Igarashi K, Kataoka K, Itoh K, Hayashi N, Nishizawa M, Yamamoto M (1994). "Regulation of transcription by dimerization of erythroid factor NF-E2 p45 with small Maf proteins". Nature. 367 (6463): 568–72. Bibcode:1994Natur.367..568I. doi:10.1038/367568a0. PMID 8107826. S2CID 4339431.
• Chan JY, Han XL, Kan YW (1994). "Isolation of cDNA encoding the human NF-E2 protein". Proc. Natl. Acad. Sci. U.S.A. 90 (23): 11366–70. doi:10.1073/pnas.90.23.11366. PMC 47983. PMID 8248255.
• Toki T, Itoh J, Kitazawa J, Arai K, Hatakeyama K, Akasaka J, Igarashi K, Nomura N, Yokoyama M, Yamamoto M, Ito E (1997). "Human small Maf proteins form heterodimers with CNC family transcription factors and recognize the NF-E2 motif". Oncogene. 14 (16): 1901–10. doi:10.1038/sj.onc.1201024. PMID 9150357.
• Blank V, Kim MJ, Andrews NC (1997). "Human MafG is a functional partner for p45 NF-E2 in activating globin gene expression". Blood. 89 (11): 3925–35. doi:10.1182/blood.V89.11.3925. PMID 9166829.
• Gavva NR, Gavva R, Ermekova K, Sudol M, Shen CJ (1997). "Interaction of WW domains with hematopoietic transcription factor p45/NF-E2 and RNA polymerase II". J. Biol. Chem. 272 (39): 24105–8. doi:10.1074/jbc.272.39.24105. PMID 9305852.
• Mosser EA, Kasanov JD, Forsberg EC, Kay BK, Ney PA, Bresnick EH (1998). "Physical and functional interactions between the transactivation domain of the hematopoietic transcription factor NF-E2 and WW domains". Biochemistry. 37 (39): 13686–95. doi:10.1021/bi981310l. PMID 9753456.
• Hung HL, Kim AY, Hong W, Rakowski C, Blobel GA (2001). "Stimulation of NF-E2 DNA binding by CREB-binding protein (CBP)-mediated acetylation". J. Biol. Chem. 276 (14): 10715–21. doi:10.1074/jbc.M007846200. PMID 11154691.
• Gavva NR, Wen SC, Daftari P, Moniwa M, Yang WM, Yang-Feng LP, Seto E, Davie JR, Shen CK (2002). "NAPP2, a peroxisomal membrane protein, is also a transcriptional corepressor". Genomics. 79 (3): 423–31. doi:10.1006/geno.2002.6714. PMID 11863372.
• Boulanger L, Sabatino DE, Wong EY, Cline AP, Garrett LJ, Garbarz M, Dhermy D, Bodine DM, Gallagher PG (2003). "Erythroid expression of the human alpha-spectrin gene promoter is mediated by GATA-1- and NF-E2-binding proteins". J. Biol. Chem. 277 (44): 41563–70. doi:10.1074/jbc.M208184200. PMID 12196550.
• Marini MG, Asunis I, Chan K, Chan JY, Kan YW, Porcu L, Cao A, Moi P (2003). "Cloning MafF by recognition site screening with the NFE2 tandem repeat of HS2: analysis of its role in globin and GCSl genes regulation". Blood Cells Mol. Dis. 29 (2): 145–58. doi:10.1006/bcmd.2002.0550. PMID 12490281.
• Onishi Y, Kiyama R (2003). "Interaction of NF-E2 in the human beta-globin locus control region before chromatin remodeling". J. Biol. Chem. 278 (10): 8163–71. doi:10.1074/jbc.M209612200. PMID 12509425.
• Newman JR, Keating AE (2003). "Comprehensive identification of human bZIP interactions with coiled-coil arrays". Science. 300 (5628): 2097–101. Bibcode:2003Sci...300.2097N. doi:10.1126/science.1084648. PMID 12805554. S2CID 36715183.
• Chuen CK, Li K, Yang M, Fok TF, Li CK, Chui CM, Yuen PM (2004). "Interleukin-1beta up-regulates the expression of thrombopoietin and transcription factors c-Jun, c-Fos, GATA-1, and NF-E2 in megakaryocytic cells". J. Lab. Clin. Med. 143 (2): 75–88. doi:10.1016/j.lab.2003.09.006. PMID 14966463.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

External links

• NFE2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• FactorBook NF-E2

This article incorporates text from the United States National Library of Medicine, which is in the public domain.