NDST3

Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3 is an enzyme that in humans is encoded by the NDST3 gene.^[5][6] It catalyses the reaction:

3'-phosphoadenylyl sulfate + α-D-glucosaminyl-[heparan sulfate]_(n) = adenosine 3',5'-bisphosphate + 2 H⁺ + N-sulfo-α-D-glucosaminyl-[heparan sulfate]_(n)^[7]

NDST3
Identifiers
Aliases	NDST3, HSST3, N-deacetylase/N-sulfotransferase 3, N-deacetylase and N-sulfotransferase 3
External IDs	OMIM: 603950; MGI: 1932544; HomoloGene: 3513; GeneCards: NDST3; OMA:NDST3 - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q26 Start 118,033,618 bp[1] End 118,258,634 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 G1 Start 123,319,815 bp[2] End 123,484,502 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell cerebellar cortex cerebellar hemisphere testicle right hemisphere of cerebellum prefrontal cortex ganglionic eminence nucleus accumbens Brodmann area 9 right frontal lobe Top expressed in cerebellar cortex spermatid primary visual cortex seminiferous tubule superior frontal gyrus lumbar subsegment of spinal cord neural layer of retina inferior colliculi dentate gyrus of hippocampal formation granule cell cerebellar vermis More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity sulfotransferase activity catalytic activity hydrolase activity [heparan sulfate-glucosamine N-sulfotransferase activity] heparan sulfate N-acetylglucosaminyltransferase activity deacetylase activity heparan sulfate sulfotransferase activity Cellular component integral component of membrane Golgi membrane Golgi apparatus membrane cellular component Biological process metabolism heparin biosynthetic process heparan sulfate proteoglycan biosynthetic process heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process glycosaminoglycan biosynthetic process sulfur compound metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9348 83398 Ensembl ENSG00000164100 ENSMUSG00000027977 UniProt O95803 Q9EQH7 RefSeq (mRNA) NM_004784 NM_001293682 NM_031186 RefSeq (protein) NP_004775 NP_001280611 NP_112463 Location (UCSC) Chr 4: 118.03 – 118.26 Mb Chr 3: 123.32 – 123.48 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

This is a step in the production of heparin.^[7]

Clinical significance

Mutations in NDST3 have been linked to schizophrenia.^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000164100 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027977 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Aikawa J, Esko JD (Mar 1999). "Molecular cloning and expression of a third member of the heparan sulfate/heparin GlcNAc N-deacetylase/ N-sulfotransferase family". J Biol Chem. 274 (5): 2690–5. doi:10.1074/jbc.274.5.2690. PMID 9915799.
6. "Entrez Gene: NDST3 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3".
7. "NDST3 – Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3 – Homo sapiens (Human) – NDST3 gene & protein". www.uniprot.org. Retrieved 2020-01-15.
8. Zhang, C; Lu, W; Wang, Z; Ni, J; Zhang, J; Tang, W; Fang, Y (January 2016). "A comprehensive analysis of NDST3 for schizophrenia and bipolar disorder in Han Chinese". Translational Psychiatry. 6 (1): e701. doi:10.1038/tp.2015.199. ISSN 2158-3188. PMC 5068873. PMID 26731438.

Further reading

• Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi:10.1038/nature03466. PMID 15815621.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Aikawa J, Grobe K, Tsujimoto M, Esko JD (2001). "Multiple isozymes of heparan sulfate/heparin GlcNAc N-deacetylase/GlcN N-sulfotransferase. Structure and activity of the fourth member, NDST4". J. Biol. Chem. 276 (8): 5876–82. doi:10.1074/jbc.M009606200. PMID 11087757.
• Sanger Centre, The; Washington University Genome Sequencing Cente, The (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.
• Boutry M, Vassarotti A, Ghislain M, et al. (1984). "Isolation of the structural genes for the alpha and beta subunits of the mitochondrial ATPase from the fission yeast Schizosaccharomyces pombe". J. Biol. Chem. 259 (5): 2840–4. doi:10.1016/S0021-9258(17)43223-6. PMID 6230352.