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N-Acetylglutamic acid
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N-Acetylglutamic acid (also referred to as N-acetylglutamate, abbreviated NAG, chemical formula C7H11NO5)[2] is biosynthesized from glutamate and acetylornithine by ornithine acetyltransferase, and from glutamic acid and acetyl-CoA by the enzyme N-acetylglutamate synthase. The reverse reaction, hydrolysis of the acetyl group, is catalyzed by a specific hydrolase. It is the first intermediate involved in the biosynthesis of arginine in prokaryotes and simple eukaryotes and a regulator in the process known as the urea cycle that converts toxic ammonia to urea for excretion from the body in vertebrates.
Quick Facts Names, Identifiers ...
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Names | |
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IUPAC name
2-Acetamidopentanedioic acid[1] | |
Other names | |
Identifiers | |
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3D model (JSmol) |
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3DMet | |
Abbreviations |
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1727473 S | |
ChEBI | |
ChemSpider | |
DrugBank |
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ECHA InfoCard | 100.024.899 ![]() |
EC Number |
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KEGG |
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MeSH | N-acetylglutamate |
PubChem CID |
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RTECS number |
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UNII |
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CompTox Dashboard (EPA) |
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Properties | |
C7H11NO5 | |
Molar mass | 189.167 g·mol−1 |
Appearance | White crystals |
Density | 1 g mL−1 |
Melting point | 191 to 194 °C (376 to 381 °F; 464 to 467 K) |
36 g L−1 | |
Hazards | |
Lethal dose or concentration (LD, LC): | |
LD50 (median dose) |
>7 g kg−1 (oral, rat) |
Related compounds | |
Related alkanoic acids |
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Related compounds |
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Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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