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Muscimol
Neurotransmission inhibitor / From Wikipedia, the free encyclopedia
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Muscimol is a potent psychoactive compound found in certain mushrooms, most notably the Amanita muscaria and related species of mushroom. Muscimol is a potent and selective orthosteric agonist for the GABAA receptor.[3]
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Names | |
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IUPAC name
5-(Aminomethyl)-1,2-oxazol-3(2H)-one | |
Other names
Agarin, Pantherine, Agarine, Pantherin | |
Identifiers | |
3D model (JSmol) |
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774694 | |
ChEBI | |
ChEMBL | |
ChemSpider |
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ECHA InfoCard | 100.018.574 ![]() |
EC Number |
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KEGG |
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PubChem CID |
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UNII | |
UN number | 2811 3077 |
CompTox Dashboard (EPA) |
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Properties[1] | |
C4H6N2O2 | |
Molar mass | 114.104 g·mol−1 |
Melting point | 184 to 185 °C (363 to 365 °F; 457 to 458 K) |
very soluble | |
Solubility in ethanol | slightly soluble |
Solubility in methanol | very soluble |
Pharmacology | |
Legal status |
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Hazards | |
GHS labelling:[2] | |
H300 | |
P264, P270, P301+P316, P321, P330, P405, P501 | |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Muscimol, an agonist for the GABAA receptor, was able to significantly alleviate pain in its peak effect, recent studies from 2023 show. Muscimol, through its potent interaction with GABA-A receptors, exerts significant effects on the central nervous system. Its ability to enhance inhibitory neurotransmission and protect neurons from excitotoxic damage makes it a compound of great interest in neuropharmacology. The diverse pharmacological effects of muscimol, from neuroprotection and pain relief to cognitive modulation and anticonvulsant properties, underscore its therapeutic potential across a range of neurological and psychiatric disorders.[4] Ongoing research continues to explore and expand upon the applications of muscimol in medicine.