Mukaiyama hydration
From Wikipedia, the free encyclopedia
The Mukaiyama hydration is an organic reaction involving formal addition of an equivalent of water across an olefin by the action of catalytic bis(acetylacetonato)cobalt(II) complex, phenylsilane and atmospheric oxygen to produce an alcohol with Markovnikov selectivity.[1]
![General scheme of Mukaiyama hydration](http://upload.wikimedia.org/wikipedia/commons/thumb/f/fb/General_scheme.tif/lossless-page1-640px-General_scheme.tif.png)
The reaction was developed by Teruaki Mukaiyama at Mitsui Petrochemical Industries, Ltd. Its discovery was based on previous work on the selective hydrations of olefins catalyzed by cobalt complexes with Schiff base ligands[2] and porphyrin ligands.[3] Due to its chemoselectivity (tolerant of other functional groups) and mild reactions conditions (run under air at room temperature), the Mukaiyama hydration has become a valuable tool in chemical synthesis.