Muckle–Wells syndrome
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Muckle–Wells syndrome (MWS) is a rare autosomal dominant disease which causes sensorineural deafness and recurrent hives, and can lead to amyloidosis. Individuals with MWS often have episodic fever, chills, and joint pain. As a result, MWS is considered a type of periodic fever syndrome. MWS is caused by a defect in the CIAS1 gene which creates the protein cryopyrin. MWS is closely related to two other syndromes, familial cold urticaria and neonatal onset multisystem inflammatory disease—in fact, all three are related to mutations in the same gene and subsumed under the term cryopyrin-associated periodic syndromes (CAPS).
You can help expand this article with text translated from the corresponding article in German. (December 2023) Click [show] for important translation instructions.
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Quick Facts Other names, Specialty ...
Muckle–Wells syndrome | |
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Other names | Urticaria-deafness-amyloidosis syndrome (UDA),[1] |
This condition is inherited in an autosomal dominant manner | |
Specialty | Clinical Immunology |
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