Neonatal-onset multisystem inflammatory disease
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Neonatal-onset multisystem inflammatory disease is a rare genetic periodic fever syndrome which causes uncontrolled inflammation in multiple parts of the body starting in the newborn period. Symptoms include skin rashes, severe arthritis, and chronic meningitis leading to neurologic damage. It is one of the cryopyrin-associated periodic syndromes.
Neonatal-onset multisystem inflammatory disease | |
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Other names | Chronic infantile neurologic cutaneous and articular syndrome,[1]: 149 or CINCA |
Specialty | Neurology, dermatology, rheumatology ![]() |
NOMID can result from a mutation in the CIAS1 gene (also known as NLRP3 gene), which helps control inflammation. Mutations in this gene also cause familial cold urticaria and Muckle–Wells syndrome. NOMID has been successfully treated with the drug anakinra.
This syndrome is also known as the Prieur–Griscelli syndrome as it was first described by these authors in 1981.[2]