Minimal change disease
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Minimal change disease (MCD), also known as lipoid nephrosis or nil disease, among others, is a disease affecting the kidneys which causes nephrotic syndrome.[1] Nephrotic syndrome leads to the loss of significant amounts of protein in the urine, which causes the widespread edema (soft tissue swelling) and impaired kidney function commonly experienced by those affected by the disease.[1] It is most common in children and has a peak incidence at 2 to 6 years of age.[2] MCD is responsible for 10–25% of nephrotic syndrome cases in adults.[3] It is also the most common cause of nephrotic syndrome of unclear cause (idiopathic) in children.[3]
Minimal change disease | |
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The three hallmarks of minimal change disease (seen on electron microscopy): diffuse loss of podocyte foot processes, vacuolation, and the appearance of microvilli. | |
Specialty | Nephrology |