The mineralocorticoid receptor (or MR, MLR, MCR), also known as the aldosterone receptor or nuclear receptor subfamily 3, group C, member 2, (NR3C2) is a protein that in humans is encoded by the NR3C2 gene that is located on chromosome 4q31.1-31.2.[5]
Quick Facts NR3C2, Available structures ...
NR3C2 |
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![](//upload.wikimedia.org/wikipedia/commons/thumb/3/36/PBB_Protein_NR3C2_image.jpg/250px-PBB_Protein_NR3C2_image.jpg) |
Available structures |
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PDB | Ortholog search: PDBe RCSB |
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List of PDB id codes |
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1Y9R, 1YA3, 2A3I, 2AA2, 2AA5, 2AA6, 2AA7, 2AAX, 2AB2, 2ABI, 2OAX, 3VHU, 3VHV, 3WFF, 3WFG, 4PF3, 4TNT, 4UDB, 4UDA, 5HCV |
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Identifiers |
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Aliases | NR3C2, MCR, MLR, MR, NR3C2VIT, nuclear receptor subfamily 3 group C member 2 |
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External IDs | OMIM: 600983; MGI: 99459; HomoloGene: 121495; GeneCards: NR3C2; OMA:NR3C2 - orthologs |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - endothelial cell
- mucosa of colon
- mucosa of sigmoid colon
- rectum
- middle temporal gyrus
- Epithelium of choroid plexus
- mucosa of ileum
- Brodmann area 23
- Achilles tendon
- jejunal mucosa
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| Top expressed in | - subdivision of hippocampus
- Region I of hippocampus proper
- hippocampus proper
- left colon
- lateral septal nucleus
- dentate gyrus
- facial motor nucleus
- ciliary body
- subiculum
- dentate gyrus of hippocampal formation granule cell
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| More reference expression data |
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BioGPS | |
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Wikidata |
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Close
MR is a receptor with equal affinity for mineralocorticoids and glucocorticoids. It belongs to the nuclear receptor family where the ligand diffuses into cells, interacts with the receptor and results in a signal transduction affecting specific gene expression in the nucleus. The selective response of some tissues and organs to mineralocorticoids over glucocorticoids occurs because mineralocorticoid-responsive cells express Corticosteroid 11-beta-dehydrogenase isozyme 2, an enzyme which selectively inactivates glucocorticoids more readily than mineralocorticoids.