Mecillinam
Pharmaceutical drug / From Wikipedia, the free encyclopedia
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Mecillinam (INN) or amdinocillin (USAN) is an extended-spectrum penicillin antibiotic of the amidinopenicillin class that binds specifically to penicillin binding protein 2 (PBP2),[2] and is only considered to be active against Gram-negative bacteria. It is used primarily in the treatment of urinary tract infections, and has also been used to treat typhoid and paratyphoid fever.[3][4] Because mecillinam has very low oral bioavailability, an orally active prodrug was developed: pivmecillinam.
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Trade names | Coactin, Leo, Selexid, Selexidin |
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Routes of administration | Intravenous, intramuscular |
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Bioavailability | Negligible |
Protein binding | 5 to 10% |
Metabolism | Some hepatic metabolism |
Elimination half-life | 1 to 3 hours |
Excretion | Renal and biliary, mostly unchanged |
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ECHA InfoCard | 100.046.601 |
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Formula | C15H23N3O3S |
Molar mass | 325.43 g·mol−1 |
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