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Maprotiline
Antidepressant / From Wikipedia, the free encyclopedia
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Maprotiline, sold under the brand name Ludiomil among others, is a tetracyclic antidepressant (TeCA) that is used in the treatment of depression.[5] It may alternatively be classified as a tricyclic antidepressant (TCA), specifically a secondary amine.[5] In terms of its chemistry and pharmacology, maprotiline is closely related to such-other secondary-amine TCAs as nortriptyline and protriptyline and has similar effects to them,[6][5] albeit with more distinct anxiolytic effects.[7][8][9] Additionally, whereas protriptyline tends to be somewhat more stimulating and in any case is distinctly more-or-less non-sedating,[10] mild degrees of sedation may be experienced with maprotiline.[11]
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Clinical data | |
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Trade names | Ludiomil, others |
Other names | Maprotiline hydrochloride; Maprotiline methanesulfonate; Ba 34276[1][2][3] |
AHFS/Drugs.com | Monograph |
MedlinePlus | a682158 |
Routes of administration | Oral, intramuscular, intravenous |
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Bioavailability | 66–70% |
Protein binding | 88% |
Metabolism | hepatic |
Onset of action | 6 hours |
Elimination half-life | 27–58 hours |
Excretion | Urine (57%) and bile (30%) as glucuronides, 3–4% as unchanged drug |
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ECHA InfoCard | 100.030.532 ![]() |
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Formula | C20H23N |
Molar mass | 277.411 g·mol−1 |
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