MOS (gene)

Proto-oncogene serine/threonine-protein kinase mos is an enzyme that in humans is encoded by the MOS gene.^[5][6]

MOS
Identifiers
Aliases	MOS, MSV, v-mos Moloney murine sarcoma viral oncogene homolog, MOS proto-oncogene, serine/threonine kinase
External IDs	OMIM: 190060; MGI: 97052; HomoloGene: 3919; GeneCards: MOS; OMA:MOS - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q12.1 Start 56,112,942 bp[1] End 56,113,982 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 A1|4 2.16 cM Start 3,870,657 bp[2] End 3,872,105 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte secondary oocyte pancreatic ductal cell tibialis anterior muscle stromal cell of endometrium testicle left testis right testis hippocampal formation hippocampus proper Top expressed in primary oocyte secondary oocyte zygote embryo spermatid embryo blastocyst ventricular zone ovary spermatocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity protein binding MAP kinase kinase kinase activity ATP binding kinase activity protein serine/threonine kinase activity signal transducer activity Cellular component cytoplasm cytosol Biological process protein autophosphorylation establishment of meiotic spindle orientation chromatin organization meiotic spindle organization phosphorylation MAPK cascade intracellular signal transduction positive regulation of MAPK cascade negative regulation of metaphase/anaphase transition of meiotic cell cycle protein phosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4342 17451 Ensembl ENSG00000172680 ENSMUSG00000078365 UniProt P00540 P00536 RefSeq (mRNA) NM_005372 NM_020021 RefSeq (protein) NP_005363 NP_064405 Location (UCSC) Chr 8: 56.11 – 56.11 Mb Chr 4: 3.87 – 3.87 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

MOS (gene) has been shown to interact with MyoD.^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000172680 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000078365 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Singh B, Arlinghaus RB (May 1998). "Mos and the cell cycle". Progress in Cell Cycle Research. Vol. 3. Springer. pp. 251–9. doi:10.1007/978-1-4615-5371-7_20. ISBN 978-1-4613-7451-0. PMID 9552420. {{cite book}}: |journal= ignored (help)
6. "Entrez Gene: MOS v-mos Moloney murine sarcoma viral oncogene homolog".
7. Lenormand JL, Benayoun B, Guillier M, Vandromme M, Leibovitch M P, Leibovitch S A (Feb 1997). "Mos activates myogenic differentiation by promoting heterodimerization of MyoD and E12 proteins". Mol. Cell. Biol. 17 (2). UNITED STATES: 584–93. doi:10.1128/mcb.17.2.584. ISSN 0270-7306. PMC 231783. PMID 9001211.

Further reading

• Sagata N (1997). "What does Mos do in oocytes and somatic cells?". BioEssays. 19 (1): 13–21. doi:10.1002/bies.950190105. PMID 9008413. S2CID 1338222.
• Caubet JF, Mathieu-Mahul D, Bernheim A, et al. (1986). "Human proto-oncogene c-mos maps to 8q11". EMBO J. 4 (9): 2245–8. doi:10.1002/j.1460-2075.1985.tb03921.x. PMC 554492. PMID 3000766.
• Watson R, Oskarsson M, Vande Woude GF (1982). "Human DNA sequence homologous to the transforming gene (mos) of Moloney murine sarcoma virus". Proc. Natl. Acad. Sci. U.S.A. 79 (13): 4078–82. Bibcode:1982PNAS...79.4078W. doi:10.1073/pnas.79.13.4078. PMC 346580. PMID 6287464.
• Heikinheimo O, Lanzendorf SE, Baka SG, Gibbons WE (1995). "Cell cycle genes c-mos and cyclin-B1 are expressed in a specific pattern in human oocytes and preimplantation embryos". Hum. Reprod. 10 (3): 699–707. doi:10.1093/oxfordjournals.humrep.a136019. PMID 7540181.
• Lenormand JL, Benayoun B, Guillier M, et al. (1997). "Mos activates myogenic differentiation by promoting heterodimerization of MyoD and E12 proteins". Mol. Cell. Biol. 17 (2): 584–93. doi:10.1128/mcb.17.2.584. PMC 231783. PMID 9001211.
• Liu H, Vuyyuru VB, Pham CD, et al. (1999). "Evidence of an interaction between Mos and Hsp70: a role of the Mos residue serine 3 in mediating Hsp70 association". Oncogene. 18 (23): 3461–70. doi:10.1038/sj.onc.1202699. PMID 10376524. S2CID 28232420.
• Pham CD, Vuyyuru VB, Yang Y, et al. (1999). "Evidence for an important role of serine 16 and its phosphorylation in the stabilization of c-Mos". Oncogene. 18 (30): 4287–94. doi:10.1038/sj.onc.1202804. PMID 10439036. S2CID 24274024.
• Proikas-Cezanne T, Stabel S, Riethmacher D (2002). "Identification of protein tyrosine phosphatase 1B and casein as substrates for 124-v-Mos". BMC Biochem. 3: 6. doi:10.1186/1471-2091-3-6. PMC 102758. PMID 12022922.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Hassel S, Eichner A, Yakymovych M, et al. (2004). "Proteins associated with type II bone morphogenetic protein receptor (BMPR-II) and identified by two-dimensional gel electrophoresis and mass spectrometry". Proteomics. 4 (5): 1346–58. doi:10.1002/pmic.200300770. PMID 15188402. S2CID 6773754.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Kalejs M, Ivanov A, Plakhins G, et al. (2006). "Upregulation of meiosis-specific genes in lymphoma cell lines following genotoxic insult and induction of mitotic catastrophe". BMC Cancer. 6: 6. doi:10.1186/1471-2407-6-6. PMC 1351196. PMID 16401344.