January 1821 – Charles Bathurst succeeds Canning as President of the Board of Control, remaining also at the Duchy of Lancaster
January 1822 – Robert Peel succeeds Lord Sidmouth as Home Secretary
February 1822 – Charles Williams-Wynn succeeds Charles Bathurst at the Board of Control. Bathurst remains at the Duchy of Lancaster and in the Cabinet
September 1822 – Following the suicide of Lord Londonderry, George Canning becomes Foreign Secretary and Leader of the House of Commons
January 1823 – Vansittart, elevated to the peerage as Lord Bexley, succeeds Charles Bathurst as Chancellor of the Duchy of Lancaster. F.J. Robinson succeeds Vansittart as Chancellor of the Exchequer. He is succeeded at the Board of Trade by William Huskisson
1823 – Lord Maryborough, the Master of the Mint, leaves the Cabinet. His successor in the office is not a Cabinet member