- Wessel Gansfort (1419–1489), theologian and early humanist
- Volcher Coiter (1534–1576), anatomist, founder of comparative osteology and first to identify cerebrospinal meningitis
- Christiaan Coevershoff (1595–1659), Dutch Golden Age painter
- Egbert Bartholomeusz Kortenaer (1604–1665), admiral
- Adriaan Geerts Wildervanck (1605–1661), businessman and coloniser[1]
- Albert Eckhout (c.1610–1665), portrait and still life painter
- Roche Braziliano (c.1630–c.1671), pirate
- Joris Andringa (1635–1676), naval officer
- Tiberius Hemsterhuis (1685–1766), philologist and critic
- Albert Schultens (1686–1750), philologist
- Daniel Bernoulli (1700–1782), mathematician and physicist
- Johannes Antiquus (1702–1750), painter
- Albertus Antonius Hinsz (1704–1785), organ-builder
- Bernard II van Risamburgh (c.1710—c.1767), cabinetmaker
- Willem Arnold Alting (1724–1800), Governor-General of the Dutch East Indies from 1780 until 1797
- Elisabeth Wassenbergh (1729–1781), painter
- Etta Palm d'Aelders (1743–1799), early feminist and spy
- Leopold von Goeckingk (1748–1828), German lyric poet, journalist and Prussian official.
- Johann August Just (c.1750–c.1791), pianist, violinist, and composer
- Abel Janszoon Tasman (1603–1659), explorer, seafarer, merchant for the Dutch East India Company
- John Goodricke (1764–1786), astronomer, observed the variable star Algol
- Albert Dominicus Trip van Zoudtlandt (1776—1835), lieutenant-general at the Battle of Waterloo
- Petrus Hofman Peerlkamp (1786–1865), classical scholar and critic.
- Geert Adriaans Boomgaard (1788–1899), first validated supercentenarian and last living veteran of Napoleon's Grande Armée
- Coos Cremers (1806-1882), politician, member of the Senate from 1850 to 1877
- Schelto van Heemstra, Baron Heemstra (1807–1864), politician, Prime minister from 1861 to 1862.
- Jozef Israëls (1824–1911), painter of the Hague School
- Joseph Ascher (1829–1869), composer and pianist
- Hendrik Willem Mesdag (1831–1915), marine art painter
- Samuel van Houten (1837–1930), politician, cabinet minister, founder of the Liberal Party
- Alexander de Savornin Lohman (1837–1924), politician, leader of the Christian Historical Union
- Otto Eerelman (1839–1926), painter, known for his depictions of dogs and horses
- Klaas Plantinga (1846–1922), distiller, founded the Plantinga Distillery
- Heike Kamerlingh Onnes (1853–1926), Nobel laureate physicist who pioneered refrigeration and superconductivity
- Gerard Bolland (1854–1922), autodidact, linguist, philosopher, biblical scholar and lecturer
- René de Marees van Swinderen (1860–1955), diplomat and politician
- Barbara Elisabeth van Houten (1863–1950), painter
- Gerrit van Houten (1866–1934), painter and artist
- Dirk Jan de Geer (1870–1960), Dutch Prime Minister (1926–29, 1939–40)
- Jantina Tammes (1871–1947), botanist and geneticist, first professor of genetics in the Netherlands.
- Johan Huizinga (1872–1945), historian
- Jaap Eden (1873–1925), only male athlete to have won world championships in both speed skating and cycling
- Bert Nienhuis (1873–1960), ceramist, designer, and jewelry designer
- Gerrit David Gratama (1874–1965), artist, writer, and director of the Frans Hals Museum
- Jan Gratama (1877–1947), architect
- Albert Hahn (1877–1918), political cartoonist, poster artist, and book cover designer
- C. U. Ariëns Kappers (1877–1946), neurologist and anatomist
- Herman de Vries de Heekelingen (1880–1942), scholar and author, professor of palaeography at the University of Nijmegen
- Julia Culp (1880–1970), mezzo-soprano
- Dirk Janssen (1881–1986), gymnast in the 1908 Summer Olympics who was 105 at the time of his death, making him the longest-lived Olympic competitor
- Jonny Heykens (1884–1945), composer of light classical music
- Wilhelm Baehrens (1885–1929), classical scholar
- Jan Janssen (1885–1953), gymnast who competed in the 1908 Summer Olympics
- Tonnis van der Heeg (1886-1958), trade unionist and political activist
- Pieter Korteweg (1888–1970), philatelist
- Alida Jantina Pott (1888–1931), artist
- Alidius Tjarda van Starkenborgh Stachouwer (1888–1978), last colonial Governor-General of the Netherlands East Indies
- Jaap Kunst (1891–1960), ethnomusicologist
- Michel Velleman (1895–1943), Jewish magician
- Hendrik de Vries (1896–1989), poet and painter, early surrealist
- Paul Schuitema (1897–1973), graphic artist
- Ulbo de Sitter (1902–1980), geologist at Leiden University, founder of school of structural geology
- Jan Wolthuis (1903–1983), lawyer and collaborator, active in far-right politics after WWII
- Hans Dirk de Vries Reilingh (1908–2001), geographer and professor
- Elie Aron Cohen (1909–1993), doctor, Auschwitz survivor
- Theodoor Overbeek (1911–2007), professor of physical chemistry at Utrecht University
- Pieter Meindert Schreuder (1912–1945), resistance leader
- Lucas Hoving (1912–2000), modern dancer, choreographer and teacher
- Jacob B. Bakema (1914–1981), modernist architect
- Anno Smith (1915–1990), artist, ceramist, painter, sculptor, and art teacher
- Jan C. Uiterwijk (1915–2005), entrepreneur and shipping line owner
- Andries Jan Pieters (1916–1952), collaborator, executed for war crimes
- Evert Musch (1918–2007), painter and professor at Academie Minerva
- Dirk Boonstra (1920–1944), active in the WWII resistance movement, caught and executed
- Poppe Damave (1921–1988), painter
- Selma Engel-Wijnberg (1922–2018), Jewish Holocaust survivor
- Henk Visser (1923–2006), arms and armory collector
- Jan Drenth (born 1925), chemist, was professor of structural chemistry at the University of Groningen
- Cor Edskes (1925–2015), authority on the history of organ music and building
- Wim Crouwel (born 1928), graphic designer, type designer and typographer.
- Maarten Schmidt (1929–2022), astronomer named and optically identified a quasar
- Jan Borgman (born 1929), astronomer and university administrator
- Dirk Bolt (born 1930), architect and town planner in Australia
- Ida Vos (1931–2006), writer and poet
- Arie van Deursen (1931–2011), early modern period historian
- Nico Habermann (1932–1993), computer scientist
- Gerrit Krol (1934−2013), author, essayist and writer
- Ad van Luyn (born 1935), Roman Catholic bishop
- Bert de Vries (born 1938), politician
- Andries van Dam (born 1938), professor of computer science at Brown University
- Wim T. Schippers (born 1942), artist, comedian, television director and voice actor
- Driek van Wissen (1943–2010), poet
- Chas Gerretsen (born 1943), war photographer, photo journalist
- Martha Vonk-van Kalker (1943–2022), Senator
- Joanna Gash (born 1944), Australian politician
- Corrie Winkel (born 1944), backstroke swimmer and silver medalist 1964 Summer Olympics
- Jan Sloot (1945–1999), inventor, claimed to have invented a revolutionary data compression technique
- Andy Anstett (born 1946), Dutch-born Canadian politician
- Wubbo Ockels (1946–2014), physicist and astronaut of the European Space Agency
- Alphons Orie (born 1947), lawyer specialising in criminal law
- Alfred Lagarde (1948–1998), voice actor
- Diederik Grit (1949–2012), translator and translation scholar
- Sierd Cloetingh (born 1950), professor of earth sciences at Utrecht University
- Pete Hoekstra (born 1953), United States ambassador to the Netherlands
- Ellen van Wolde (born 1954), biblical scholar
- Hanneke Kappen (born 1954), singer, radio and TV presenter
- Rob Nanninga (1955–2014), skeptic, writer, board member of Stichting Skepsis
- Bert Meijer (born 1955), organic chemist
- Gerard de Korte (born 1955), Roman Catholic bishop
- Joep Franssens (born 1955), composer
- Jan van der Kooi (born 1957), painter of figurative art
- Anita Buma (born 1958), pioneer Antarctic researcher
- Tjibbe Veldkamp (born 1962), author of children's books
- Wilma Mansveld (born 1962), politician
- Aernout Mik (born 1962), artist
- Peter Hofstee (born 1962), physicist and computer scientist
- Hans van den Hende (born 1964), Roman Catholic bishop
- Gerard Kemkers (born 1967), speed skating bronze medalist at 1988 Winter Olympics
- Didy Veldman (born 1967), choreographer
- J. Maarten Troost (born 1969), travel writer
- Stephan Veen (born 1970), field hockey player in the 1996 and 2000 Summer Olympics
- Sharon Dijksma (born 1971), politician
- Diederik Samsom (born 1971), politician
- Michiel van Veen (born 1971), politician
- Attje Kuiken (born 1977), politician and former civil servant
- Rudmer Heerema (born 1978), politician
- Rutger Smith (born 1981), track and field athlete
- Henk Nijboer (born 1983), politician
- Sophie Polkamp (born 1984), field hockey athlete, two-time Olympic champion
- Kim Feenstra (born 1985), model
- Marijn Nijman (born 1985), former international cricketer
- Manja Smits (born 1985), politician
- Bauke Mollema (born 1986), cyclist
- Lorena Klijn (born 1987), kickboxer
- Tom-Jelte Slagter (born 1989), professional road racing cyclist
- Lois Abbingh (1992), handball player
- Jur P. van den Berg (born 1981), computer engineer
- Jorden van Foreest (born 1999), chess grandmaster
- kim velleman (age 43 ), hero of groningen