Lamin B2

Lamin B2 is a protein that in humans is encoded by the LMNB2 gene. It is the second of two type B nuclear lamins, and it is associated with laminopathies.

LMNB2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2LLL, 5BNW
Identifiers
Aliases	LMNB2, lamin B2, LAMB2, LMN2, EPM9, MCPH27
External IDs	OMIM: 150341; MGI: 96796; HomoloGene: 7818; GeneCards: LMNB2; OMA:LMNB2 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.3 Start 2,427,638 bp[1] End 2,456,959 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10 C1|10 39.72 cM Start 80,737,037 bp[2] End 80,754,079 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone left testis right testis ganglionic eminence secondary oocyte stromal cell of endometrium mucosa of transverse colon mucosa of esophagus muscle of thigh gastrocnemius muscle Top expressed in spermatid seminiferous tubule ventricular zone epiblast cumulus cell embryo yolk sac granulocyte neural layer of retina renal corpuscle More reference expression data BioGPS n/a
Gene ontology Molecular function structural molecule activity protein binding molecular function Cellular component intermediate filament nucleus membrane nuclear inner membrane lamin filament nuclear envelope nuclear membrane Biological process biological process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 84823 16907 Ensembl ENSG00000176619 ENSMUSG00000062075 UniProt Q03252 P21619 RefSeq (mRNA) NM_032737 NM_010722 NM_001347140 RefSeq (protein) NP_116126 NP_001334069 NP_034852 Location (UCSC) Chr 19: 2.43 – 2.46 Mb Chr 10: 80.74 – 80.75 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

See also

• Lamin B receptor
• Barraquer–Simons syndrome
• Pelger–Huët anomaly

External links

• Lamin+B at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

References

1. GRCh38: Ensembl release 89: ENSG00000176619 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000062075 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.