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LINGO1
Protein-coding gene in the species Homo sapiens / From Wikipedia, the free encyclopedia
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Leucine rich repeat and Immunoglobin-like domain-containing protein 1[5] also known as LINGO-1 is a protein which is encoded by the LINGO1 gene in humans.[6][7] It belongs to the family of leucine-rich repeat proteins which are known for playing key roles[8] in the biology of the central nervous system. LINGO-1 is a functional component of the Nogo (neurite outgrowth inhibitor) receptor also known as the reticulon 4 receptor.
Quick Facts Available structures, PDB ...
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Aliases | LINGO1, LERN1, LRRN6A, UNQ201, leucine rich repeat and Ig domain containing 1, MRT64 | ||||||||||||||||||||||||||||||
External IDs | OMIM: 609791; MGI: 1915522; HomoloGene: 41891; GeneCards: LINGO1; OMA:LINGO1 - orthologs | ||||||||||||||||||||||||||||||
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It has been suggested that LINGO-1 antagonists such as BIIB033[9] could significantly improve and regulate survival after neural injury caused by the protein.[10]