LAMP1
Protein-coding gene in the species Homo sapiens / From Wikipedia, the free encyclopedia
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Lysosomal-associated membrane protein 1 (LAMP-1) also known as lysosome-associated membrane glycoprotein 1 and CD107a (Cluster of Differentiation 107a), is a protein that in humans is encoded by the LAMP1 gene. The human LAMP1 gene is located on the long arm (q) of chromosome 13 at region 3, band 4 (13q34).
Lysosomal-associated membrane protein 1 is a glycoprotein from a family of Lysosome-associated membrane glycoproteins.[5] The LAMP-1 glycoprotein is a type I transmembrane protein[6] which is expressed at high or medium levels in at least 76 different normal tissue cell types.[7] It resides primarily across lysosomal membranes,[8] and functions to provide selectins with carbohydrate ligands.[5] CD107a has also been shown to be a marker of degranulation on lymphocytes such as CD8+ and NK cells,[9] and may also play a role in tumor cell differentiation and metastasis.