KTN1

Kinectin is a protein that in humans is encoded by the KTN1 gene.^[5][6]

KTN1
Identifiers
Aliases	KTN1, CG1, KNT, MU-RMS-40.19, kinectin 1
External IDs	OMIM: 600381; MGI: 109153; HomoloGene: 135663; GeneCards: KTN1; OMA:KTN1 - orthologs
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q22.3 Start 55,559,072 bp[1] End 55,701,526 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 C1 Start 47,885,905 bp[2] End 47,977,351 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm glutes Skeletal muscle tissue of rectus abdominis biceps brachii Skeletal muscle tissue of biceps brachii Epithelium of choroid plexus renal medulla mucosa of paranasal sinus epithelium of colon vastus lateralis muscle Top expressed in tail of embryo triceps brachii muscle temporal muscle sternocleidomastoid muscle genital tubercle digastric muscle epithelium of lens muscle of thigh neural layer of retina right ventricle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding kinesin binding RNA binding cadherin binding Cellular component integral component of membrane integral component of plasma membrane endoplasmic reticulum membrane endoplasmic reticulum membrane endoplasmic reticulum lumen Biological process microtubule-based movement post-translational protein modification Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3895 16709 Ensembl ENSG00000126777 ENSMUSG00000021843 UniProt Q86UP2 Q61595 RefSeq (mRNA) NM_001079521 NM_001079522 NM_001271014 NM_004986 NM_182926 NM_001293635 NM_001293636 NM_008477 NM_001347519 NM_001347520 NM_001347521 NM_001347522 NM_001347523 NM_001347524 NM_001347525 NM_001347526 NM_001347527 NM_001347528 NM_001379486 NM_001379487 NM_001379488 NM_001379489 NM_001379490 NM_001379491 NM_001379492 NM_001379493 NM_001379494 NM_001379495 RefSeq (protein) NP_001072989 NP_001072990 NP_001257943 NP_004977 NP_001280564 NP_001280565 NP_001334448 NP_001334449 NP_001334450 NP_001334451 NP_001334452 NP_001334453 NP_001334454 NP_001334455 NP_001334456 NP_001334457 NP_032503 NP_001366415 NP_001366416 NP_001366417 NP_001366418 NP_001366419 NP_001366420 NP_001366421 NP_001366422 NP_001366423 NP_001366424 Location (UCSC) Chr 14: 55.56 – 55.7 Mb Chr 14: 47.89 – 47.98 Mb PubMed search [3] [4]
Wikidata
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Function

Various cellular organelles and vesicles are transported along the microtubules in the cytoplasm. Likewise, membrane recycling of the endoplasmic reticulum (ER), Golgi assembly at the microtubule organizing center, and alignment of lysosomes along microtubules are all related processes. The transport of organelles requires a special class of microtubule-associated proteins (MAPs). One of these is the molecular motor kinesin (see MIM 148760 and MIM 600025), an ATPase that moves vesicles unidirectionally toward the plus end of the microtubule. Another such MAP is kinectin, a large integral ER membrane protein. Antibodies directed against kinectin have been shown to inhibit its binding to kinesin.[supplied by OMIM]^[6]

Interactions

KTN1 has been shown to interact with EEF1D,^[7] RhoG^[8][9] and RHOA.^{[8][9][10][11]}

References

1. GRCh38: Ensembl release 89: ENSG00000126777 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000021843 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Rao PN, Yu H, Hodge R, Pettenati MJ, Sheetz MP (1997). "Assignment of the human kinectin gene (KTN1), encoding a kinesin-binding protein, to chromosome 14 band q22.1 by in situ hybridization". Cytogenet. Cell Genet. 79 (3–4): 196–7. doi:10.1159/000134719. PMID 9605849.
6. "Entrez Gene: KTN1 kinectin 1 (kinesin receptor)".
7. Ong LL, Er CP, Ho A, Aung MT, Yu H (Aug 2003). "Kinectin anchors the translation elongation factor-1 delta to the endoplasmic reticulum". J. Biol. Chem. 278 (34): 32115–23. doi:10.1074/jbc.M210917200. PMID 12773547.
8. Neudauer CL, Joberty G, Macara IG (Jan 2001). "PIST: a novel PDZ/coiled-coil domain binding partner for the rho-family GTPase TC10". Biochem. Biophys. Res. Commun. 280 (2): 541–7. doi:10.1006/bbrc.2000.4160. PMID 11162552.
9. Vignal E, Blangy A, Martin M, Gauthier-Rouvière C, Fort P (Dec 2001). "Kinectin is a key effector of RhoG microtubule-dependent cellular activity". Mol. Cell. Biol. 21 (23): 8022–34. doi:10.1128/MCB.21.23.8022-8034.2001. PMC 99969. PMID 11689693.
10. Riento K, Guasch RM, Garg R, Jin B, Ridley AJ (Jun 2003). "RhoE binds to ROCK I and inhibits downstream signaling". Mol. Cell. Biol. 23 (12): 4219–29. doi:10.1128/MCB.23.12.4219-4229.2003. PMC 156133. PMID 12773565.
11. Hotta K, Tanaka K, Mino A, Kohno H, Takai Y (Aug 1996). "Interaction of the Rho family small G proteins with kinectin, an anchoring protein of kinesin motor". Biochem. Biophys. Res. Commun. 225 (1): 69–74. doi:10.1006/bbrc.1996.1132. PMID 8769096.

Further reading

• Nomura N, Miyajima N, Sazuka T, Tanaka A, Kawarabayasi Y, Sato S, Nagase T, Seki N, Ishikawa K, Tabata S (1994). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1". DNA Res. 1 (1): 27–35. doi:10.1093/dnares/1.1.27. PMID 7584026.
• Nomura N, Miyajima N, Sazuka T, Tanaka A, Kawarabayasi Y, Sato S, Nagase T, Seki N, Ishikawa K, Tabata S (1994). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement)". DNA Res. 1 (1): 47–56. doi:10.1093/dnares/1.1.47. PMID 7584028.
• Fütterer A, Kruppa G, Krämer B, Lemke H, Krönke M (1995). "Molecular cloning and characterization of human kinectin". Mol. Biol. Cell. 6 (2): 161–70. doi:10.1091/mbc.6.2.161. PMC 275826. PMID 7787243.
• Yu H, Nicchitta CV, Kumar J, Becker M, Toyoshima I, Sheetz MP (1995). "Characterization of kinectin, a kinesin-binding protein: primary sequence and N-terminal topogenic signal analysis". Mol. Biol. Cell. 6 (2): 171–83. doi:10.1091/mbc.6.2.171. PMC 275827. PMID 7787244.
• Print CG, Leung E, Harrison JE, Watson JD, Krissansen GW (1994). "Cloning of a gene encoding a human leukocyte protein characterised by extensive heptad repeats". Gene. 144 (2): 221–8. doi:10.1016/0378-1119(94)90381-6. PMID 8039706.
• Print CG, Morris CM, Spurr NK, Rooke L, Krissansen GW (1996). "The CG-1 gene, a member of the kinectin and ES/130 family, maps to human chromosome band 14q22". Immunogenetics. 43 (4): 227–9. doi:10.1007/BF00587304. PMID 8575822.
• Hotta K, Tanaka K, Mino A, Kohno H, Takai Y (1996). "Interaction of the Rho family small G proteins with kinectin, an anchoring protein of kinesin motor". Biochem. Biophys. Res. Commun. 225 (1): 69–74. doi:10.1006/bbrc.1996.1132. PMID 8769096.
• Alberts AS, Bouquin N, Johnston LH, Treisman R (1998). "Analysis of RhoA-binding proteins reveals an interaction domain conserved in heterotrimeric G protein beta subunits and the yeast response regulator protein Skn7". J. Biol. Chem. 273 (15): 8616–22. doi:10.1074/jbc.273.15.8616. PMID 9535835.
• Vancoillie G, Lambert J, Mulder A, Koerten HK, Mommaas AM, Van Oostveldt P, Naeyaert JM (2000). "Kinesin and kinectin can associate with the melanosomal surface and form a link with microtubules in normal human melanocytes". J. Invest. Dermatol. 114 (3): 421–9. doi:10.1046/j.1523-1747.2000.00896.x. PMID 10692099.
• Salassidis K, Bruch J, Zitzelsberger H, Lengfelder E, Kellerer AM, Bauchinger M (2000). "Translocation t(10;14)(q11.2:q22.1) fusing the kinetin to the RET gene creates a novel rearranged form (PTC8) of the RET proto-oncogene in radiation-induced childhood papillary thyroid carcinoma". Cancer Res. 60 (11): 2786–9. PMID 10850414.
• Ong LL, Lim AP, Er CP, Kuznetsov SA, Yu H (2000). "Kinectin-kinesin binding domains and their effects on organelle motility". J. Biol. Chem. 275 (42): 32854–60. doi:10.1074/jbc.M005650200. PMID 10913441.
• Harrington JJ, Sherf B, Rundlett S, Jackson PD, Perry R, Cain S, Leventhal C, Thornton M, Ramachandran R, Whittington J, Lerner L, Costanzo D, McElligott K, Boozer S, Mays R, Smith E, Veloso N, Klika A, Hess J, Cothren K, Lo K, Offenbacher J, Danzig J, Ducar M (2001). "Creation of genome-wide protein expression libraries using random activation of gene expression". Nat. Biotechnol. 19 (5): 440–5. doi:10.1038/88107. PMID 11329013. S2CID 25064683.
• Vignal E, Blangy A, Martin M, Gauthier-Rouvière C, Fort P (2001). "Kinectin is a key effector of RhoG microtubule-dependent cellular activity". Mol. Cell. Biol. 21 (23): 8022–34. doi:10.1128/MCB.21.23.8022-8034.2001. PMC 99969. PMID 11689693.
• Tran H, Pankov R, Tran SD, Hampton B, Burgess WH, Yamada KM (2002). "Integrin clustering induces kinectin accumulation". J. Cell Sci. 115 (Pt 10): 2031–40. doi:10.1242/jcs.115.10.2031. PMID 11973345.
• Ong LL, Er CP, Ho A, Aung MT, Yu H (2003). "Kinectin anchors the translation elongation factor-1 delta to the endoplasmic reticulum". J. Biol. Chem. 278 (34): 32115–23. doi:10.1074/jbc.M210917200. PMID 12773547.
• Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.