Janet S. Butel

Janet S Butel is the Chairman and Distinguished Service Professor in the molecular virology and microbiology department at Baylor College of Medicine. Her area of expertise is on polyomavirus pathogenesis of infections and disease. She has more than 120 publications on PubMed. She also has 6 publications in Nature, which is considered one of the most prestigious science journals. She is a member of 9 different organizations and has 13 honors and awards.^[1]

Janet S Butel
Education	B.S. Kansas State University (1963) Ph.D. Baylor College of Medicine (1966)
Known for	Study of SV40 in humans through animal model in golden hamsters.
Awards	American Association for the Advancement of Science Fellow (1988)
Scientific career
Fields	Virology, molecular virology, immunology, microbiology
Institutions	Baylor College of Medicine

Education

Butel received her Bachelor of Science degree from Kansas State University in June 1963. She then went on to get her Ph.D. in virology at Baylor College of Medicine in June 1966. After she received her PhD she did a Post-Doctoral Fellowship in virology at Baylor College of Medicine.^[1]

Research contributions

Simian virus 40

Butel has studied polyomavirus SV40 infection in humans and animals for most of her career. She has published studies on the mechanism of SV40 entry into human cells, the role of SV40 in cancer and SV40 genetics. In addition, Butel published an article in 2014 on the use of microRNA and SV40 in golden hamsters.^[2] The golden hamster is the animal model that SV40 has been studied in and has provided evidence of its pathogenesis in tumor forming cancer.^[3] The animal model has been used to research the development of this virus in humans, but can not conclude any definitive pathogenesis of SV40 in humans.^[4] Thus there is controversy over the exact impact of SV40 on human health. Butel's research indicates that SV40 may play a role in some human cancers, such as brain tumors and non-Hodgkin lymphoma.^{[5][6][7][8][9]}

In the 1990s Dr. Butel discovered the role of P53 in the pathogenesis of SV40 and oncogenesis.^{[10][11][12][13][14][15]} By discovering the role of P53 in SV40 she was able to support the research being conducted on P53 as a tumor-suppressor gene. This was perhaps the most important research of her career.^[16][17][18]

Dr. Butel has also studied the role of the polio vaccine and in human SV40 infection and integration of SV40 into our DNA. It was found that some vaccines contained pieces of SV40 genes. It is suspected that by incorporating SV40 into the vaccine allowed it to enter into our own DNA.^[19] Butel has published studies on topics other than SV40. She has studied the immunology of women going into spaceflight, specifically cytokines and antibodies.^[20] Butel also researched hepatitis B and the role it plays in DNA repair.^[21][22] Dr. Butel has also contributed to higher education and is a coauthor of a medical microbiology textbook that has been used for over 50 years and in medical colleges around the world.^[23] Dr. Butel has over 120 publications with over 10,000 citations, according to Google scholar.

Honors and awards

• American Association for the Advancement of Science Fellow in 1988.
• Distinguished Service Professor at Baylor College of Medicine
• In 1997 she was in the Texas A&M University Press as a Women Pioneer in Texas Medicine
• Recipient of the Distinguished Alumnus of the Graduate School of Biomedical Sciences Award in 2002
• Kansas State University Alumni Fellow
• Recipient of the American Association for Cancer Research-Women in Cancer Research-Charlotte Friend Memorial Lectureship
• Kyle and Josephine Morrow Chair in Molecular Virology and Microbiology at Baylor College of Medicine
• BioHouston Women in Science Award
• Honoree at the Hearts of Gold: Honoring Women in Health and Medical Science Gala
• The Joseph L. Melnick Professor of Virology at Baylor College of Medicine

^[1]

References

1. "Janet S Butel Ph.D". Baylor College of Medicine. Baylor College. Retrieved 14 April 2015.
2. Zhang, S; Sroller, V; Zanwar, P; Chen, CJ; Halvorson, SJ; Ajami, NJ; Hecksel, CW; Swain, JL; Wong, C; Sullivan, CS; Butel, JS (February 2014). "Viral microRNA effects on pathogenesis of polyomavirus SV40 infections in syrian golden hamsters". PLOS Pathogens. 10 (2): e1003912. doi:10.1371/journal.ppat.1003912. PMC 3916418. PMID 24516384.
3. Patel, NC; Halvorson, SJ; Sroller, V; Arrington, AS; Wong, C; Smith, EO; Vilchez, RA; Butel, JS (30 March 2009). "Viral regulatory region effects on vertical transmission of polyomavirus SV40 in hamsters". Virology. 386 (1): 94–101. doi:10.1016/j.virol.2008.12.040. PMC 2668977. PMID 19181358.
4. Sroller, V; Vilchez, RA; Stewart, AR; Wong, C; Butel, JS (January 2008). "Influence of the viral regulatory region on tumor induction by simian virus 40 in hamsters". Journal of Virology. 82 (2): 871–9. doi:10.1128/jvi.01626-07. PMC 2224577. PMID 17977966.
5. Vilchez, RA; Butel, JS (11 August 2003). "SV40 in human brain cancers and non-Hodgkin's lymphoma". Oncogene. 22 (33): 5164–72. doi:10.1038/sj.onc.1206547. PMID 12910253.
6. Vilchez, RA; Butel, JS (September 2003). "Simian virus 40 and its association with human lymphomas". Current Oncology Reports. 5 (5): 372–9. doi:10.1007/s11912-003-0021-y. PMID 12895387. S2CID 22078338.
7. Vilchez, RA; Kozinetz, CA; Arrington, AS; Madden, CR; Butel, JS (1 June 2003). "Simian virus 40 in human cancers". The American Journal of Medicine. 114 (8): 675–84. doi:10.1016/s0002-9343(03)00087-1. PMID 12798456.
8. Butel, JS; Jafar, S; Stewart, AR; Lednicky, JA (1998). "Detection of authentic SV40 DNA sequences in human brain and bone tumours". Developments in Biological Standardization. 94: 23–32. PMID 9776222.
9. McNees, AL; Vilchez, RA; Heard, TC; Sroller, V; Wong, C; Herron, AJ; Hamilton, MJ; Davis, WC; Butel, JS (5 February 2009). "SV40 lymphomagenesis in Syrian golden hamsters". Virology. 384 (1): 114–24. doi:10.1016/j.virol.2008.10.035. PMC 3648995. PMID 19038412.
10. Maxwell, SA; Ames, SK; Sawai, ET; Decker, GL; Cook, RG; Butel, JS (February 1991). "Simian virus 40 large T antigen and p53 are microtubule-associated proteins in transformed cells". Cell Growth & Differentiation. 2 (2): 115–27. PMID 1648952.
11. Scorsone, KA; Zhou, YZ; Butel, JS; Slagle, BL (15 March 1992). "p53 mutations cluster at codon 249 in hepatitis B virus-positive hepatocellular carcinomas from China". Cancer Research. 52 (6): 1635–8. PMID 1311638.
12. Donehower, LA; Harvey, M; Slagle, BL; McArthur, MJ; Montgomery CA, Jr; Butel, JS; Bradley, A (19 March 1992). "Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours". Nature. 356 (6366): 215–21. Bibcode:1992Natur.356..215D. doi:10.1038/356215a0. PMID 1552940. S2CID 4348340.
13. Ozbun, MA; Jerry, DJ; Kittrell, FS; Medina, D; Butel, JS (1 April 1993). "p53 mutations selected in vivo when mouse mammary epithelial cells form hyperplastic outgrowths are not necessary for establishment of mammary cell lines in vitro". Cancer Research. 53 (7): 1646–52. PMID 8453637.
14. Jerry, DJ; Ozbun, MA; Kittrell, FS; Lane, DP; Medina, D; Butel, JS (15 July 1993). "Mutations in p53 are frequent in the preneoplastic stage of mouse mammary tumor development". Cancer Research. 53 (14): 3374–81. PMID 8324748.
15. Ozbun, MA; Medina, D; Butel, JS (October 1993). "p53 mutations in mouse mammary epithelial cells: instability in culture and discordant selection of mutations in vitro versus in vivo". Cell Growth & Differentiation. 4 (10): 811–9. PMID 8274450.
16. Harvey, M; McArthur, MJ; Montgomery CA, Jr; Butel, JS; Bradley, A; Donehower, LA (November 1993). "Spontaneous and carcinogen-induced tumorigenesis in p53-deficient mice". Nature Genetics. 5 (3): 225–9. doi:10.1038/ng1193-225. PMID 8275085. S2CID 26741712.
17. Ozbun, MA; Butel, JS (1995). "Tumor suppressor p53 mutations and breast cancer: a critical analysis". Advances in Cancer Research. 66: 71–141. doi:10.1016/s0065-230x(08)60252-3. ISBN 9780120066667. PMID 7793321.
18. Medina, D; Stephens, LC; Bonilla, PJ; Hollmann, CA; Schwahn, D; Kuperwasser, C; Jerry, DJ; Butel, JS; Meyn, RE (July 1998). "Radiation-induced tumorigenesis in preneoplastic mouse mammary glands in vivo: significance of p53 status and apoptosis". Molecular Carcinogenesis. 22 (3): 199–207. doi:10.1002/(sici)1098-2744(199807)22:3<199::aid-mc8>3.0.co;2-g. PMID 9688146. S2CID 25526449.
19. Shah, Keerti V. (15 January 2007). "SV40 and human cancer: A review of recent data". International Journal of Cancer. 120 (2): 215–223. doi:10.1002/ijc.22425. PMID 17131333. S2CID 20679358.
20. Shearer, WT; Ochs, HD; Lee, BN; Cohen, EN; Reuben, JM; Cheng, I; Thompson, B; Butel, JS; Blancher, A; Abbal, M; Aviles, H; Sonnenfeld, G (April 2009). "Immune responses in adult female volunteers during the bed-rest model of spaceflight: antibodies and cytokines". The Journal of Allergy and Clinical Immunology. 123 (4): 900–5. doi:10.1016/j.jaci.2008.12.016. PMID 19232702.
21. Becker, SA; Lee, TH; Butel, JS; Slagle, BL (January 1998). "Hepatitis B virus X protein interferes with cellular DNA repair". Journal of Virology. 72 (1): 266–72. doi:10.1128/JVI.72.1.266-272.1998. PMC 109372. PMID 9420223.
22. Butel, JS; Lee, TH; Slagle, BL (March 1996). "Is the DNA repair system involved in hepatitis-B-virus-mediated hepatocellular carcinogenesis?". Trends in Microbiology. 4 (3): 119–24. doi:10.1016/0966-842x(96)81529-0. PMID 8868091.
23. Brooks, George; Butel, Janet; Morse, Stephen (June 1, 2004). Jawtz, melnick and adelbergs medical microbiology (3 ed.). McGraw-Hill Medical. ISBN 978-0071239837.