Irbesartan
Chemical compound / From Wikipedia, the free encyclopedia
Irbesartan, sold under the brand name Aprovel among others, is a medication used to treat high blood pressure, heart failure, and diabetic kidney disease.[5] It is a reasonable initial treatment for high blood pressure.[5] It is taken by mouth.[5] Versions are available as the combination irbesartan/hydrochlorothiazide.[5][6][7]
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Pronunciation | /ɜːrbəˈsɑːrtən/ |
Trade names | Aprovel, Avapro, others |
AHFS/Drugs.com | Monograph |
MedlinePlus | a698009 |
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Routes of administration | By mouth |
Drug class | Cardiovascular agent |
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Bioavailability | 60% to 80% |
Protein binding | ~90% |
Metabolism | Liver (CYP2C9) |
Elimination half-life | 11 h to 15 h |
Excretion | Kidney 20%, feces 65% |
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ECHA InfoCard | 100.119.966 |
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Formula | C25H28N6O |
Molar mass | 428.540 g·mol−1 |
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Common side effects include dizziness, diarrhea, feeling tired, muscle pain, and heartburn.[5][8] Serious side effects may include kidney problems, low blood pressure, and angioedema.[5] Use in pregnancy may harm the baby and use when breastfeeding is not recommended.[9] It is an angiotensin II receptor antagonist and works by blocking the effects of angiotensin II.[5]
Irbesartan was patented in 1990, and approved for medical use in 1997.[10] It is available as a generic medication.[8] In 2021, it was the 172nd most commonly prescribed medication in the United States, with more than 3 million prescriptions.[11][12]