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Interleukin 32
Protein-coding gene in the species Homo sapiens / From Wikipedia, the free encyclopedia
Interleukin 32 (IL32) is proinflammatory cytokine that in humans is encoded by the IL32 gene.[3] Interleukin 32 can be found in higher mammals but not in rodents. It is mainly expressed intracellularly and the protein has nine different isoforms, because the pre-mRNA can be alternatively spliced.[4][5] The most active and studied isoform is IL-32γ. It was first reported in 2005,[6] although the IL-32 gene was first described in 1992.[7] It does not belong to any cytokine family because there is almost no homology with other cytokines.[5]
mRNA of IL-32 is mostly expressed in immune cells but also can be expressed in other tissues such as spleen, thymus, lung, small intestine, colon, prostate, heart, placenta, liver, muscle, kidney, pancreas and brain.[4][5]
Interleukin 32 is connected with several diseases, including cancer.