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Interleukin 31
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"IL-31" redirects here. For the road, see Illinois Route 31.
Interleukin-31 (IL-31) is a protein that in humans is encoded by the IL31 gene that resides on chromosome 12.[5][6][7] IL-31 is an inflammatory cytokine that helps trigger cell-mediated immunity against pathogens. It has also been identified as a major player in a number of chronic inflammatory diseases, including atopic dermatitis.[7][8]
Quick Facts IL31, Identifiers ...
IL31 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Aliases | IL31, IL-31, interleukin 31 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 609509; MGI: 1923649; HomoloGene: 88541; GeneCards: IL31; OMA:IL31 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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IL-31 is produced by a variety of cells, namely type 2 helper (TH2) T-cells.[7] IL-31 sends signals through a receptor complex made of IL-31RA and oncostatin M receptor β (OSMRβ) expressed in immune and epithelial cells.[9] These signals activate three pathways: ERK1/2 MAP kinase, PI3K/AKT, and JAK1/2 signaling pathways.[7][8]