Integrin beta-5 is a protein that in humans is encoded by the ITGB5 gene.[5][6]
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Integrin, beta 5 has been shown to interact with PTK2,[7] Annexin A5[8] and PAK4.[9]
ITGB5 encodes a subunit of integrin that can interact with several alpha chains to form a variety of integrin heterodimers. It also plays a potential role in intercellular communication during tumor progression and metastasis.[10]
Research
Elevated levels of ITGB5 have been found in patients with autosomal dominant osteopetrosis type II, a rare disease of bones.[11]
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- Hu DD, Lin EC, Kovach NL, et al. (1995). "A biochemical characterization of the binding of osteopontin to integrins alpha v beta 1 and alpha v beta 5". J. Biol. Chem. 270 (44): 26232–8. doi:10.1074/jbc.270.44.26232. PMID 7592829.
- Vogel BE, Lee SJ, Hildebrand A, et al. (1993). "A novel integrin specificity exemplified by binding of the alpha v beta 5 integrin to the basic domain of the HIV Tat protein and vitronectin". J. Cell Biol. 121 (2): 461–8. doi:10.1083/jcb.121.2.461. PMC 2200091. PMID 7682219.
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- Lafrenie RM, Wahl LM, Epstein JS, et al. (1996). "HIV-1-Tat protein promotes chemotaxis and invasive behavior by monocytes". Journal of Immunology. 157 (3): 974–7. doi:10.4049/jimmunol.157.3.974. PMID 8757599.
- Rabb H, Barroso-Vicens E, Adams R, et al. (1997). "Alpha-V/beta-3 and alpha-V/beta-5 integrin distribution in neoplastic kidney". Am. J. Nephrol. 16 (5): 402–8. doi:10.1159/000169032. PMID 8886177.
- Liliental J, Chang DD (1998). "Rack1, a receptor for activated protein kinase C, interacts with integrin beta subunit". J. Biol. Chem. 273 (4): 2379–83. doi:10.1074/jbc.273.4.2379. PMID 9442085.
- Memmo LM, McKeown-Longo P (1998). "The alphavbeta5 integrin functions as an endocytic receptor for vitronectin". J. Cell Sci. 111 (4): 425–33. doi:10.1242/jcs.111.4.425. PMID 9443892.
- Zhang H, Tan SM, Lu J (1998). "cDNA cloning reveals two mouse beta5 integrin transcripts distinct in cytoplasmic domains as a result of alternative splicing". Biochem. J. 331 (2): 631–7. doi:10.1042/bj3310631. PMC 1219398. PMID 9531507.
- Barillari G, Sgadari C, Palladino C, et al. (1999). "Inflammatory cytokines synergize with the HIV-1 Tat protein to promote angiogenesis and Kaposi's sarcoma via induction of basic fibroblast growth factor and the alpha v beta 3 integrin". Journal of Immunology. 163 (4): 1929–35. doi:10.4049/jimmunol.163.4.1929. PMID 10438928.
- Carriero MV, Del Vecchio S, Capozzoli M, et al. (1999). "Urokinase receptor interacts with alpha(v)beta5 vitronectin receptor, promoting urokinase-dependent cell migration in breast cancer". Cancer Res. 59 (20): 5307–14. PMID 10537314.
- Tang S, Gao Y, Ware JA (1999). "Enhancement of endothelial cell migration and in vitro tube formation by TAP20, a novel beta 5 integrin-modulating, PKC theta-dependent protein". J. Cell Biol. 147 (5): 1073–84. doi:10.1083/jcb.147.5.1073. PMC 2169340. PMID 10579726.
- Cirulli V, Beattie GM, Klier G, et al. (2000). "Expression and function of alpha(v)beta(3) and alpha(v)beta(5) integrins in the developing pancreas: roles in the adhesion and migration of putative endocrine progenitor cells". J. Cell Biol. 150 (6): 1445–60. doi:10.1083/jcb.150.6.1445. PMC 2150716. PMID 10995448.
- Albert ML, Kim JI, Birge RB (2001). "alphavbeta5 integrin recruits the CrkII-Dock180-rac1 complex for phagocytosis of apoptotic cells". Nat. Cell Biol. 2 (12): 899–905. doi:10.1038/35046549. PMID 11146654. S2CID 7535200.
- Zhou M, Graham R, Russell G, Croucher PI (2001). "MDC-9 (ADAM-9/Meltrin gamma) functions as an adhesion molecule by binding the alpha(v)beta(5) integrin". Biochem. Biophys. Res. Commun. 280 (2): 574–80. doi:10.1006/bbrc.2000.4155. PMID 11162558.
- Niu JK, Zhang WJ, Ye LY, Wu LQ, Zhu GJ, Yang ZH, Grau GE, Lou JN (2007). "The role of adhesion molecules, alpha v beta 3, alpha v beta 5 and their ligands in the tumor cell and endothelial cell adhesion". Eur J Cancer Prev. 16 (6): 517–27. doi:10.1097/CEJ.0b013e3280145c00. PMID 18090124. S2CID 1825380.