Integrin alpha 2

Integrin alpha-2, or CD49b (cluster of differentiation 49b), is a protein which in humans is encoded by the CD49b gene.

ITGA2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1AOX, 1DZI, 1V7P, 4BJ3
Identifiers
Aliases	ITGA2, BR, CD49B, GPIa, HPA-5, VLA-2, VLAA2, integrin subunit alpha 2
External IDs	OMIM: 192974; MGI: 96600; HomoloGene: 1662; GeneCards: ITGA2; OMA:ITGA2 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q11.2 Start 52,989,340 bp[1] End 53,094,779 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13 D2.2|13 64.61 cM Start 114,969,617 bp[2] End 115,068,636 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone epithelium of nasopharynx bronchial epithelial cell islet of Langerhans visceral pleura skin of thigh skin of hip gingival epithelium seminal vesicula vulva Top expressed in gastrula cumulus cell lumbar spinal ganglion molar blood trigeminal ganglion Paneth cell decidua left lung lobe stellate reticulum More reference expression data BioGPS n/a
Gene ontology Molecular function collagen binding virus receptor activity protein-containing complex binding collagen receptor activity metal ion binding integrin binding protein binding collagen binding involved in cell-matrix adhesion protein heterodimerization activity laminin binding amyloid-beta binding heparan sulfate proteoglycan binding Cellular component axon terminus integral component of membrane cell projection membrane focal adhesion basal part of cell plasma membrane cell surface integrin complex axon integrin alpha2-beta1 complex perinuclear region of cytoplasm external side of plasma membrane nucleus Biological process positive regulation of collagen biosynthetic process positive regulation of inflammatory response response to hypoxia positive regulation of phagocytosis, engulfment skin morphogenesis response to organic cyclic compound collagen-activated signaling pathway positive regulation of leukocyte migration establishment of protein localization positive regulation of transmission of nerve impulse female pregnancy cellular response to estradiol stimulus cellular response to organic cyclic compound hepatocyte differentiation positive regulation of epithelial cell migration blood coagulation extracellular matrix organization positive regulation of cell projection organization response to L-ascorbic acid wound healing positive regulation of translation substrate-dependent cell migration mammary gland development positive regulation of smooth muscle cell migration focal adhesion assembly cell-substrate adhesion cellular response to mechanical stimulus cell adhesion response to parathyroid hormone cell adhesion mediated by integrin positive regulation of alkaline phosphatase activity response to amine hypotonic response animal organ morphogenesis mesodermal cell differentiation integrin-mediated signaling pathway positive regulation of collagen binding viral entry into host cell positive regulation of DNA binding cell-matrix adhesion cell population proliferation viral process positive regulation of smooth muscle contraction response to muscle activity positive regulation of cell adhesion positive regulation of smooth muscle cell proliferation positive regulation of positive chemotaxis detection of mechanical stimulus involved in sensory perception of pain Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3673 16398 Ensembl ENSG00000164171 ENSMUSG00000015533 UniProt P17301 Q62469 RefSeq (mRNA) NM_002203 NM_008396 RefSeq (protein) NP_002194 NP_032422 Location (UCSC) Chr 5: 52.99 – 53.09 Mb Chr 13: 114.97 – 115.07 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

The CD49b protein is an integrin alpha subunit. It makes up half of the α2β1 integrin duplex. Integrins are heterodimeric integral membrane glycoproteins composed of a distinct alpha chain and a common beta chain. They are found on a wide variety of cell types including T cells (the NKT cells), NK cells, fibroblasts and platelets. Integrins are involved in cell adhesion and also participate in cell-surface-mediated signalling.^[5]

Expression of CD49b in conjunction with LAG-3 has been used to identify type 1 regulatory (Tr1) cells.^[6]

The DX5 monoclonal antibody recognizes mouse CD49b.^[7]

Interactions

CD49b has been shown to interact with MMP1.^[8][9]

References

1. GRCh38: Ensembl release 89: ENSG00000164171 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000015533 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)".
6. Gagliani N, Magnani CF, Huber S, Gianolini ME, Pala M, Licona-Limon P, Guo B, Herbert DR, Bulfone A (2013-06-01). "Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells". Nature Medicine. 19 (6): 739–746. doi:10.1038/nm.3179. ISSN 1546-170X. PMID 23624599. S2CID 21305032.
7. Arase H, Saito T, Phillips JH, Lanier LL (August 2001). "Cutting edge: the mouse NK cell-associated antigen recognized by DX5 monoclonal antibody is CD49b (alpha 2 integrin, very late antigen-2)". Journal of Immunology. 167 (3): 1141–4. doi:10.4049/jimmunol.167.3.1141. PMID 11466327.
8. Stricker TP, Dumin JA, Dickeson SK, Chung L, Nagase H, Parks WC, Santoro SA (Aug 2001). "Structural analysis of the alpha(2) integrin I domain/procollagenase-1 (matrix metalloproteinase-1) interaction". J. Biol. Chem. 276 (31): 29375–81. doi:10.1074/jbc.M102217200. PMID 11359774.
9. Dumin JA, Dickeson SK, Stricker TP, Bhattacharyya-Pakrasi M, Roby JD, Santoro SA, Parks WC (Aug 2001). "Pro-collagenase-1 (matrix metalloproteinase-1) binds the alpha(2)beta(1) integrin upon release from keratinocytes migrating on type I collagen". J. Biol. Chem. 276 (31): 29368–74. doi:10.1074/jbc.M104179200. PMID 11359786.

External links

• CD49b+antigen at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• PDBe-KB provides an overview of all the structure information available in the PDB for Human Integrin alpha 2

Further reading

• Moroi M, Jung SM (1997). "Platelet receptors for collagen". Thromb. Haemost. 78 (1): 439–44. doi:10.1055/s-0038-1657566. PMID 9198193. S2CID 8121197.
• Takada Y, Kamata T, Irie A, Puzon-McLaughlin W, Zhang XP (1998). "Structural basis of integrin-mediated signal transduction". Matrix Biol. 16 (4): 143–51. doi:10.1016/S0945-053X(97)90002-0. PMID 9402003.
• Dickeson SK, Santoro SA (1998). "Ligand recognition by the I domain-containing integrins". Cell. Mol. Life Sci. 54 (6): 556–66. doi:10.1007/s000180050184. PMC 11147323. PMID 9676575. S2CID 9775686.
• Porter JC, Hogg N (1999). "Integrins take partners: cross-talk between integrins and other membrane receptors". Trends Cell Biol. 8 (10): 390–6. doi:10.1016/S0962-8924(98)01344-0. PMID 9789327.
• Plenz GA, Deng MC, Robenek H, Völker W (2003). "Vascular collagens: spotlight on the role of type VIII collagen in atherogenesis". Atherosclerosis. 166 (1): 1–11. doi:10.1016/S0021-9150(01)00766-3. PMID 12482545.
• Charakida M, Tousoulis D, Stefanadis C, Toutouzas P (2003). "The impact of platelet glycoprotein IIIa and Ia polymorphisms in cardiovascular thrombotic disease". Italian Heart Journal. 4 (1): 17–22. PMID 12690916.
• Tsantes AE, Nikolopoulos GK, Bagos PG, Vaiopoulos G, Travlou A (2007). "Lack of association between the platelet glycoprotein Ia C807T gene polymorphism and coronary artery disease: a meta-analysis". Int. J. Cardiol. 118 (2): 189–96. doi:10.1016/j.ijcard.2006.06.047. PMID 17023078.

External links

• ITGA2 Info with links in the Cell Migration Gateway Archived 2014-12-11 at the Wayback Machine
• Human ITGA2 genome location and ITGA2 gene details page in the UCSC Genome Browser.