Integrin alpha-1

Integrin alpha-1 also CD49a is an integrin alpha subunit encoded in humans by the gene ITGA1. It makes up half of the α1β1 integrin duplex. Though CD49a can bind a number of ligands including collagen IV, collagen I, and others.^[5]

ITGA1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1PT6, 1QC5, 1QCY, 2L8S, 4A0Q, 2M32
Identifiers
Aliases	ITGA1, CD49a, VLA1, integrin subunit alpha 1
External IDs	OMIM: 192968; MGI: 96599; HomoloGene: 57137; GeneCards: ITGA1; OMA:ITGA1 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q11.2 Start 52,787,916 bp[1] End 52,959,209 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13 D2.2|13 64.61 cM Start 115,089,632 bp[2] End 115,238,500 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon gastric mucosa right coronary artery stromal cell of endometrium epithelium of colon saphenous vein right lung popliteal artery tibial arteries left coronary artery Top expressed in right lung right lung lobe umbilical cord aorta left lung lobe ascending aorta sciatic nerve brown adipose tissue vas deferens decidua More reference expression data BioGPS n/a
Gene ontology Molecular function collagen binding metal ion binding protein binding collagen binding involved in cell-matrix adhesion protein phosphatase binding signaling receptor binding Cellular component integral component of membrane perikaryon integrin alpha1-beta1 complex membrane focal adhesion basal part of cell plasma membrane cell surface integrin complex acrosomal vesicle membrane raft neuron projection extracellular exosome external side of plasma membrane Biological process neuron projection morphogenesis muscle contraction negative regulation of epidermal growth factor receptor signaling pathway extracellular matrix organization vasodilation neutrophil chemotaxis positive regulation of neuron apoptotic process positive regulation of phosphoprotein phosphatase activity cell adhesion cell chemotaxis integrin-mediated signaling pathway cellular extravasation cell-matrix adhesion negative regulation of cell population proliferation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3672 109700 Ensembl ENSG00000213949 ENSMUSG00000042284 UniProt P56199 Q3V3R4 RefSeq (mRNA) NM_181501 NM_001033228 RefSeq (protein) NP_852478 NP_001028400 Location (UCSC) Chr 5: 52.79 – 52.96 Mb Chr 13: 115.09 – 115.24 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

CD49a has been implicated as a marker of tissue resident memory T cells, where it may be coexpressed with other markers CD103 and CD69.^[6] It has been shown to affect the motility of T cells.^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000213949 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000042284 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Gardner H (2014). "Integrin α1β1". I Domain Integrins. Advances in Experimental Medicine and Biology. Vol. 819. pp. 21–39. doi:10.1007/978-94-017-9153-3_2. ISBN 978-94-017-9152-6. PMID 25023165.
6. Reilly EC, Sportiello M, Emo KL, Amitrano AM, Jha R, Kumar AB, et al. (9 September 2021). "CD49a Identifies Polyfunctional Memory CD8 T Cell Subsets that Persist in the Lungs After Influenza Infection". Frontiers in Immunology. 12: 728669. doi:10.3389/fimmu.2021.728669. PMC 8462271. PMID 34566986.
7. Reilly EC, Lambert Emo K, Buckley PM, Reilly NS, Smith I, Chaves FA, et al. (June 2020). "T_RM integrins CD103 and CD49a differentially support adherence and motility after resolution of influenza virus infection". Proceedings of the National Academy of Sciences of the United States of America. 117 (22): 12306–12314. doi:10.1073/pnas.1915681117. PMC 7275699. PMID 32439709.

Further reading

• Virtanen I, Korhonen M, Kariniemi AL, Gould VE, Laitinen L, Ylänne J (December 1990). "Integrins in human cells and tumors". Cell Differentiation and Development. 32 (3): 215–227. doi:10.1016/0922-3371(90)90034-T. PMID 2099238.
• Plenz GA, Deng MC, Robenek H, Völker W (January 2003). "Vascular collagens: spotlight on the role of type VIII collagen in atherogenesis". Atherosclerosis. 166 (1): 1–11. doi:10.1016/S0021-9150(01)00766-3. PMID 12482545.
• Clover J, Dodds RA, Gowen M (September 1992). "Integrin subunit expression by human osteoblasts and osteoclasts in situ and in culture". Journal of Cell Science. 103 ( Pt 1) (1): 267–271. doi:10.1242/jcs.103.1.267. PMID 1429908.
• Bodary SC, McLean JW (April 1990). "The integrin beta 1 subunit associates with the vitronectin receptor alpha v subunit to form a novel vitronectin receptor in a human embryonic kidney cell line". The Journal of Biological Chemistry. 265 (11): 5938–5941. doi:10.1016/S0021-9258(19)39269-5. PMID 1690718.
• Sonnenberg A, Linders CJ, Modderman PW, Damsky CH, Aumailley M, Timpl R (June 1990). "Integrin recognition of different cell-binding fragments of laminin (P1, E3, E8) and evidence that alpha 6 beta 1 but not alpha 6 beta 4 functions as a major receptor for fragment E8". The Journal of Cell Biology. 110 (6): 2145–2155. doi:10.1083/jcb.110.6.2145. PMC 2116116. PMID 1693624.
• Belkin VM, Belkin AM, Dol'nikova AE, Tarasova EA, Kotelianskiĭ VE (December 1991). "[Isolation and characteristics of ligand specificity of VLA-1 integrin from human smooth muscles]". Biokhimiia. 56 (12): 2198–2206. PMID 1807406.
• Bank I, Roth D, Book M, Guterman A, Shnirrer I, Block R, et al. (January 1991). "Expression and functions of very late antigen 1 in inflammatory joint diseases". Journal of Clinical Immunology. 11 (1): 29–38. doi:10.1007/BF00918792. PMID 1827128. S2CID 6198792.
• Tabibzadeh S (September 1990). "Evidence of T-cell activation and potential cytokine action in human endometrium". The Journal of Clinical Endocrinology and Metabolism. 71 (3): 645–649. doi:10.1210/jcem-71-3-645. PMID 2144294.
• Tawil NJ, Houde M, Blacher R, Esch F, Reichardt LF, Turner DC, et al. (July 1990). "Alpha 1 beta 1 integrin heterodimer functions as a dual laminin/collagen receptor in neural cells". Biochemistry. 29 (27): 6540–6544. doi:10.1021/bi00479a028. PMC 2710132. PMID 2169872.
• Belkin VM, Belkin AM, Koteliansky VE (November 1990). "Human smooth muscle VLA-1 integrin: purification, substrate specificity, localization in aorta, and expression during development". The Journal of Cell Biology. 111 (5 Pt 1): 2159–2170. doi:10.1083/jcb.111.5.2159. PMC 2116325. PMID 2229189.
• MacDonald TT, Horton MA, Choy MY, Richman PI (April 1990). "Increased expression of laminin/collagen receptor (VLA-1) on epithelium of inflamed human intestine". Journal of Clinical Pathology. 43 (4): 313–315. doi:10.1136/jcp.43.4.313. PMC 502365. PMID 2341567.
• Takada Y, Strominger JL, Hemler ME (May 1987). "The very late antigen family of heterodimers is part of a superfamily of molecules involved in adhesion and embryogenesis". Proceedings of the National Academy of Sciences of the United States of America. 84 (10): 3239–3243. Bibcode:1987PNAS...84.3239T. doi:10.1073/pnas.84.10.3239. PMC 304844. PMID 3033641.
• Hemler ME, Huang C, Schwarz L (March 1987). "The VLA protein family. Characterization of five distinct cell surface heterodimers each with a common 130,000 molecular weight beta subunit". The Journal of Biological Chemistry. 262 (7): 3300–3309. doi:10.1016/S0021-9258(18)61504-2. PMID 3546305.
• Kono Y, Yang S, Letarte M, Roberts EA (December 1995). "Establishment of a human hepatocyte line derived from primary culture in a collagen gel sandwich culture system". Experimental Cell Research. 221 (2): 478–485. doi:10.1006/excr.1995.1399. PMID 7493648.
• Eglinton BA, Roberton DM, Cummins AG (August 1994). "Phenotype of T cells, their soluble receptor levels, and cytokine profile of human breast milk". Immunology and Cell Biology. 72 (4): 306–313. doi:10.1038/icb.1994.46. PMID 7806264. S2CID 25016970.
• Salter DM, Godolphin JL, Gourlay MS (April 1995). "Chondrocyte heterogeneity: immunohistologically defined variation of integrin expression at different sites in human fetal knees". The Journal of Histochemistry and Cytochemistry. 43 (4): 447–457. doi:10.1177/43.4.7897185. PMID 7897185.
• Pfaff M, Aumailley M, Specks U, Knolle J, Zerwes HG, Timpl R (May 1993). "Integrin and Arg-Gly-Asp dependence of cell adhesion to the native and unfolded triple helix of collagen type VI". Experimental Cell Research. 206 (1): 167–176. doi:10.1006/excr.1993.1134. PMID 8387021.
• Briesewitz R, Epstein MR, Marcantonio EE (February 1993). "Expression of native and truncated forms of the human integrin alpha 1 subunit". The Journal of Biological Chemistry. 268 (4): 2989–2996. doi:10.1016/S0021-9258(18)53871-0. PMID 8428973.
• Langholz O, Röckel D, Mauch C, Kozlowska E, Bank I, Krieg T, et al. (December 1995). "Collagen and collagenase gene expression in three-dimensional collagen lattices are differentially regulated by alpha 1 beta 1 and alpha 2 beta 1 integrins". The Journal of Cell Biology. 131 (6 Pt 2): 1903–1915. doi:10.1083/jcb.131.6.1903. PMC 2120685. PMID 8557756.
• Gardner H, Kreidberg J, Koteliansky V, Jaenisch R (May 1996). "Deletion of integrin alpha 1 by homologous recombination permits normal murine development but gives rise to a specific deficit in cell adhesion". Developmental Biology. 175 (2): 301–313. doi:10.1006/dbio.1996.0116. PMID 8626034.

External links

• CD49a+antigen at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• Human ITGA1 genome location and ITGA1 gene details page in the UCSC Genome Browser.
• ITGA1 Info with links in the Cell Migration Gateway Archived 2014-12-11 at the Wayback Machine
• PDBe-KB provides an overview of all the structure information available in the PDB for Human Integrin alpha-1