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Chemical compound From Wikipedia, the free encyclopedia
Ilomastat (INN),[1] (codenamed GM6001, proprietary name Galardin®) is a broad-spectrum matrix metalloproteinase inhibitor.[2][3][4]
Names | |
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Preferred IUPAC name
(3R)-N1-Hydroxy-N4-{(1S)-1-[(1H-indol-3-yl)methyl]-2-(methylamino)-2-oxoethyl}-3-(2-methylpropyl)butanediamide | |
Other names
Galardin, GM6001 | |
Identifiers | |
3D model (JSmol) |
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Abbreviations | GM6 |
ChEBI | |
ChemSpider | |
DrugBank | |
MeSH | GM6001 |
PubChem CID |
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UNII | |
CompTox Dashboard (EPA) |
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Properties | |
C20H28N4O4 | |
Molar mass | 388.468 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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This chemotherapy agent is considered to have application in skincare products for its antiaging properties.
Ilomastat is a member of the hydroxamic acid class of reversible metallopeptidase inhibitors. The anionic state of the hydroxamic acid group forms a bidentate complex with the active site zinc.[5]
Examples of enzymes that ilomastat inhibit include rabbit MMP9,[6] thermolysin,[2] peptide deformylase,[7] and anthrax lethal factor endopeptidase (LF) produced by the bacterium Bacillus anthracis.[8][9]
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