IRAK3

Interleukin-1 receptor-associated kinase 3 is an enzyme that in humans is encoded by the IRAK3 gene.^[5][6] Using in vivo liposome-mediated delivery of CRISPR/Cas9 plasmid expressing IRAK3 gRNA, IRAK3 was shown to be responsible for endotoxin-induced expression of A20 and VE-cadherin in endothelial cells. Thus, IRAK3 is crucial for maintenance and repair of endothelial barrier after endotoxin-induced lung injury.^[7]

IRAK3
Identifiers
Aliases	IRAK3, ASRT5, IRAKM, interleukin 1 receptor associated kinase 3
External IDs	OMIM: 604459; MGI: 1921164; HomoloGene: 36215; GeneCards: IRAK3; OMA:IRAK3 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q14.3 Start 66,189,195 bp[1] End 66,254,622 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 D2 Start 119,977,553 bp[2] End 120,038,035 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte bone marrow parietal pleura blood right lung bone marrow cells palpebral conjunctiva spleen lower lobe of lung trabecular bone Top expressed in granulocyte gastrula spermatocyte seminiferous tubule spermatid bone marrow ankle sciatic nerve lip blood More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding protein kinase activity transferase activity magnesium ion binding protein serine/threonine kinase activity kinase activity protein homodimerization activity protein heterodimerization activity ATP binding protein binding Cellular component cytoplasm nucleus plasma membrane Biological process response to lipopolysaccharide negative regulation of innate immune response signal transduction negative regulation of macrophage cytokine production protein autophosphorylation negative regulation of protein-containing complex disassembly response to interleukin-1 response to exogenous dsRNA protein phosphorylation negative regulation of toll-like receptor signaling pathway cytokine-mediated signaling pathway response to virus response to peptidoglycan negative regulation of cytokine-mediated signaling pathway regulation of protein-containing complex disassembly positive regulation of macrophage tolerance induction negative regulation of NF-kappaB transcription factor activity phosphorylation negative regulation of protein catabolic process negative regulation of interleukin-6 production interleukin-1-mediated signaling pathway positive regulation of NF-kappaB transcription factor activity negative regulation of MAP kinase activity negative regulation of tumor necrosis factor production negative regulation of interleukin-12 production MyD88-dependent toll-like receptor signaling pathway intracellular signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11213 73914 Ensembl ENSG00000090376 ENSMUSG00000020227 UniProt Q9Y616 Q8K4B2 RefSeq (mRNA) NM_007199 NM_001142523 NM_028679 NM_001359184 RefSeq (protein) NP_001135995 NP_009130 NP_082955 NP_001346113 Location (UCSC) Chr 12: 66.19 – 66.25 Mb Chr 10: 119.98 – 120.04 Mb PubMed search [3] [4]
Wikidata
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References

1. GRCh38: Ensembl release 89: ENSG00000090376 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020227 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Wesche H, Gao X, Li X, Kirschning CJ, Stark GR, Cao Z (July 1999). "IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family". The Journal of Biological Chemistry. 274 (27): 19403–10. doi:10.1074/jbc.274.27.19403. PMID 10383454.
6. "Entrez Gene: IRAK3 interleukin-1 receptor-associated kinase 3".
7. Soni D, Wang DM, Regmi SC, Mittal M, Vogel SM, Schlüter D, Tiruppathi C (May 2018). "Deubiquitinase function of A20 maintains and repairs endothelial barrier after lung vascular injury". Cell Death Discovery. 4 (60): 60. doi:10.1038/s41420-018-0056-3. PMC 5955943. PMID 29796309.

Further reading

• Rosati O, Martin MU (May 2002). "Identification and characterization of murine IRAK-M". Biochemical and Biophysical Research Communications. 293 (5): 1472–7. doi:10.1016/S0006-291X(02)00411-4. PMID 12054681.
• Bin LH, Xu LG, Shu HB (July 2003). "TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling". The Journal of Biological Chemistry. 278 (27): 24526–32. doi:10.1074/jbc.M303451200. PMID 12721283.
• Escoll P, del Fresno C, García L, Vallés G, Lendínez MJ, Arnalich F, López-Collazo E (November 2003). "Rapid up-regulation of IRAK-M expression following a second endotoxin challenge in human monocytes and in monocytes isolated from septic patients". Biochemical and Biophysical Research Communications. 311 (2): 465–72. doi:10.1016/j.bbrc.2003.10.019. PMID 14592437.
• del Fresno C, Otero K, Gómez-García L, González-León MC, Soler-Ranger L, Fuentes-Prior P, Escoll P, Baos R, Caveda L, García F, Arnalich F, López-Collazo E (March 2005). "Tumor cells deactivate human monocytes by up-regulating IL-1 receptor associated kinase-M expression via CD44 and TLR4". Journal of Immunology. 174 (5): 3032–40. doi:10.4049/jimmunol.174.5.3032. PMID 15728517.
• Su J, Xie Q, Wilson I, Li L (July 2007). "Differential regulation and role of interleukin-1 receptor associated kinase-M in innate immunity signaling". Cellular Signalling. 19 (7): 1596–601. doi:10.1016/j.cellsig.2007.02.009. PMC 1978187. PMID 17379480.
• Balaci L, Spada MC, Olla N, Sole G, Loddo L, Anedda F, Naitza S, Zuncheddu MA, Maschio A, Altea D, Uda M, Pilia S, Sanna S, Masala M, Crisponi L, Fattori M, Devoto M, Doratiotto S, Rassu S, Mereu S, Giua E, Cadeddu NG, Atzeni R, Pelosi U, Corrias A, Perra R, Torrazza PL, Pirina P, Ginesu F, Marcias S, Schintu MG, Del Giacco GS, Manconi PE, Malerba G, Bisognin A, Trabetti E, Boner A, Pescollderungg L, Pignatti PF, Schlessinger D, Cao A, Pilia G (June 2007). "IRAK-M is involved in the pathogenesis of early-onset persistent asthma". American Journal of Human Genetics. 80 (6): 1103–14. doi:10.1086/518259. PMC 1867098. PMID 17503328.
• Weersma RK, Oostenbrug LE, Nolte IM, Van Der Steege G, Oosterom E, Van Dullemen HM, Kleibeuker JH, Dijkstra G (July 2007). "Association of interleukin-1 receptor-associated kinase M (IRAK-M) and inflammatory bowel diseases". Scandinavian Journal of Gastroenterology. 42 (7): 827–33. doi:10.1080/00365520601114024. PMID 17558906. S2CID 22703718.
• van 't Veer C, van den Pangaart PS, van Zoelen MA, de Kruif M, Birjmohun RS, Stroes ES, de Vos AF, van der Poll T (November 2007). "Induction of IRAK-M is associated with lipopolysaccharide tolerance in a human endotoxemia model". Journal of Immunology. 179 (10): 7110–20. doi:10.4049/jimmunol.179.10.7110. PMID 17982103.

External links

• Overview of all the structural information available in the PDB for UniProt: Q9Y616 (Interleukin-1 receptor-associated kinase 3) at the PDBe-KB.