IRAK2

Interleukin-1 receptor-associated kinase-like 2 is an enzyme that in humans is encoded by the IRAK2 gene.^[5][6]

IRAK2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3MOP
Identifiers
Aliases	IRAK2, IRAK-2, interleukin 1 receptor associated kinase 2
External IDs	OMIM: 603304; MGI: 2429603; HomoloGene: 1207; GeneCards: IRAK2; OMA:IRAK2 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p25.3 Start 10,164,919 bp[1] End 10,243,745 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6 E3|6 52.82 cM Start 113,615,428 bp[2] End 113,671,987 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cartilage tissue pancreatic epithelial cell secondary oocyte pancreatic ductal cell palpebral conjunctiva gastrocnemius muscle tibialis anterior muscle amniotic fluid endothelial cell islet of Langerhans Top expressed in granulocyte jejunum urinary bladder white adipose tissue spleen left lung colon proximal tubule duodenum ileum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding protein kinase activity protein homodimerization activity protein serine/threonine kinase activity protein binding protein heterodimerization activity ATP binding Cellular component cytoplasm cytosol plasma membrane endosome membrane nucleus Biological process response to interleukin-1 negative regulation of DNA-binding transcription factor activity toll-like receptor signaling pathway protein phosphorylation JNK cascade positive regulation of NF-kappaB transcription factor activity toll-like receptor 9 signaling pathway negative regulation of NF-kappaB transcription factor activity nucleotide-binding oligomerization domain containing signaling pathway lipopolysaccharide-mediated signaling pathway signal transduction regulation of cytokine-mediated signaling pathway I-kappaB kinase/NF-kappaB signaling inflammatory response MyD88-dependent toll-like receptor signaling pathway intracellular signal transduction interleukin-1-mediated signaling pathway cytokine-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3656 108960 Ensembl ENSG00000134070 ENSMUSG00000060477 UniProt O43187 Q8CFA1 RefSeq (mRNA) NM_001570 NM_001113553 NM_172161 RefSeq (protein) NP_001561 NP_001107025 NP_751893 Location (UCSC) Chr 3: 10.16 – 10.24 Mb Chr 6: 113.62 – 113.67 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

IRAK2 encodes the interleukin-1 receptor-associated kinase 2, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. IRAK2 is reported to participate in the IL1-induced upregulation of NF-kappaB.^[6]

Interactions

IRAK2 has been shown to interact with TRAF6^[5][7] and Myd88.^[5][7][8]

References

1. GRCh38: Ensembl release 89: ENSG00000134070 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000060477 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Muzio M, Ni J, Feng P, Dixit VM (Nov 1997). "IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling". Science. 278 (5343): 1612–5. Bibcode:1997Sci...278.1612M. doi:10.1126/science.278.5343.1612. PMID 9374458.
6. "Entrez Gene: IRAK2 interleukin-1 receptor-associated kinase 2".
7. Wesche H, Gao X, Li X, Kirschning CJ, Stark GR, Cao Z (Jul 1999). "IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family". The Journal of Biological Chemistry. 274 (27): 19403–10. doi:10.1074/jbc.274.27.19403. PMID 10383454.
8. Fitzgerald KA, Palsson-McDermott EM, Bowie AG, Jefferies CA, Mansell AS, Brady G, Brint E, Dunne A, Gray P, Harte MT, McMurray D, Smith DE, Sims JE, Bird TA, O'Neill LA (Sep 2001). "Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction". Nature. 413 (6851): 78–83. Bibcode:2001Natur.413...78F. doi:10.1038/35092578. PMID 11544529. S2CID 4333764.

Further reading

• Auron PE (1999). "The interleukin 1 receptor: ligand interactions and signal transduction". Cytokine & Growth Factor Reviews. 9 (3–4): 221–37. doi:10.1016/S1359-6101(98)00018-5. PMID 9918122.
• Maschera B, Ray K, Burns K, Volpe F (Apr 1999). "Overexpression of an enzymically inactive interleukin-1-receptor-associated kinase activates nuclear factor-kappaB". The Biochemical Journal. 339 ( Pt 2) (2): 227–31. doi:10.1042/0264-6021:3390227. PMC 1220149. PMID 10191251.
• Wesche H, Gao X, Li X, Kirschning CJ, Stark GR, Cao Z (Jul 1999). "IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family". The Journal of Biological Chemistry. 274 (27): 19403–10. doi:10.1074/jbc.274.27.19403. PMID 10383454.
• Fitzgerald KA, Palsson-McDermott EM, Bowie AG, Jefferies CA, Mansell AS, Brady G, Brint E, Dunne A, Gray P, Harte MT, McMurray D, Smith DE, Sims JE, Bird TA, O'Neill LA (Sep 2001). "Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction". Nature. 413 (6851): 78–83. Bibcode:2001Natur.413...78F. doi:10.1038/35092578. PMID 11544529. S2CID 4333764.
• McDermott EP, O'Neill LA (Mar 2002). "Ras participates in the activation of p38 MAPK by interleukin-1 by associating with IRAK, IRAK2, TRAF6, and TAK-1". The Journal of Biological Chemistry. 277 (10): 7808–15. doi:10.1074/jbc.M108133200. hdl:2262/33695. PMID 11744690.
• Shin BK, Wang H, Yim AM, Le Naour F, Brichory F, Jang JH, Zhao R, Puravs E, Tra J, Michael CW, Misek DE, Hanash SM (Feb 2003). "Global profiling of the cell surface proteome of cancer cells uncovers an abundance of proteins with chaperone function". The Journal of Biological Chemistry. 278 (9): 7607–16. doi:10.1074/jbc.M210455200. PMID 12493773.
• Bin LH, Xu LG, Shu HB (Jul 2003). "TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling". The Journal of Biological Chemistry. 278 (27): 24526–32. doi:10.1074/jbc.M303451200. PMID 12721283.
• Kuzmin I, Geil L, Gibson L, Cavinato T, Loukinov D, Lobanenkov V, Lerman MI (Feb 2005). "Transcriptional regulator CTCF controls human interleukin 1 receptor-associated kinase 2 promoter". Journal of Molecular Biology. 346 (2): 411–22. doi:10.1016/j.jmb.2004.11.066. PMID 15670593.
• Keating SE, Maloney GM, Moran EM, Bowie AG (Nov 2007). "IRAK-2 participates in multiple toll-like receptor signaling pathways to NFkappaB via activation of TRAF6 ubiquitination". The Journal of Biological Chemistry. 282 (46): 33435–43. doi:10.1074/jbc.M705266200. PMID 17878161.