IFNA21

Interferon alpha-21 is a protein that in humans is encoded by the IFNA21 gene.^[5][6]

IFNA21
Identifiers
Aliases	IFNA21, IFN-alphaI, LeIF F, leIF-F, interferon, alpha 21, interferon alpha 21
External IDs	OMIM: 147584; MGI: 2667155; HomoloGene: 88661; GeneCards: IFNA21; OMA:IFNA21 - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9p21.3 Start 21,165,637 bp[1] End 21,166,660 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 C4|4 42.02 cM Start 88,561,878 bp[2] End 88,562,696 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cerebellar hemisphere right hemisphere of cerebellum Brodmann area 9 hypothalamus Cortex of frontal lobe prefrontal cortex lymph node nucleus accumbens islet of Langerhans mesencephalon Top expressed in embryo embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function cytokine activity type I interferon receptor binding cytokine receptor binding Cellular component extracellular region extracellular space Biological process natural killer cell activation involved in immune response B cell differentiation defense response B cell proliferation blood coagulation positive regulation of peptidyl-serine phosphorylation of STAT protein humoral immune response adaptive immune response defense response to virus type I interferon signaling pathway response to exogenous dsRNA T cell activation involved in immune response cytokine-mediated signaling pathway innate immune response regulation of signaling receptor activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3452 230396 Ensembl ENSG00000137080 ENSMUSG00000063376 UniProt P01568 Q80SU4 RefSeq (mRNA) NM_002175 NM_177347 RefSeq (protein) NP_002166 NP_796321 Location (UCSC) Chr 9: 21.17 – 21.17 Mb Chr 4: 88.56 – 88.56 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000137080 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000063376 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Olopade OI, Bohlander SK, Pomykala H, Maltepe E, Van Melle E, Le Beau MM, Diaz MO (Dec 1992). "Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia". Genomics. 14 (2): 437–43. doi:10.1016/S0888-7543(05)80238-1. PMID 1385305.
6. "Entrez Gene: IFNA21 interferon, alpha 21".

Further reading

• Goeddel DV, Leung DW, Dull TJ, et al. (1981). "The structure of eight distinct cloned human leukocyte interferon cDNAs". Nature. 290 (5801): 20–6. Bibcode:1981Natur.290...20G. doi:10.1038/290020a0. PMID 6163083. S2CID 1900300.
• Gren E, Berzin V, Jansone I, et al. (1985). "Novel human leukocyte interferon subtype and structural comparison of alpha interferon genes". J. Interferon Res. 4 (4): 609–17. doi:10.1089/jir.1984.4.609. PMID 6548765.
• Tiefenbrun N, Melamed D, Levy N, et al. (1996). "Alpha interferon suppresses the cyclin D3 and cdc25A genes, leading to a reversible G0-like arrest". Mol. Cell. Biol. 16 (7): 3934–44. doi:10.1128/MCB.16.7.3934. PMC 231390. PMID 8668211.
• Hussain M, Gill DS, Liao MJ (1997). "Identification of interferon-alpha 7, -alpha 14, and -alpha 21 variants in the genome of a large human population". J. Interferon Cytokine Res. 16 (10): 853–9. doi:10.1089/jir.1996.16.853. PMID 8910771.
• Kawaguchi N, Yamada T, Yoshiyama Y (1997). "[Expression of interferon-alpha mRNA in human brain tissues]". No to Shinkei. 49 (1): 69–73. PMID 9027905.
• Nyman TA, Tölö H, Parkkinen J, Kalkkinen N (1998). "Identification of nine interferon-alpha subtypes produced by Sendai virus-induced human peripheral blood leucocytes". Biochem. J. 329 (Pt 2): 295–302. doi:10.1042/bj3290295. PMC 1219044. PMID 9425112.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.