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IDH3A
Protein-coding gene in the species Homo sapiens / From Wikipedia, the free encyclopedia
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Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial (IDH3α) is an enzyme that in humans is encoded by the IDH3A gene.[5][6]
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Aliases | IDH3A, isocitrate dehydrogenase 3 (NAD(+)) alpha, isocitrate dehydrogenase (NAD(+)) 3 alpha, isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha, RP90 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 601149; MGI: 1915084; HomoloGene: 4037; GeneCards: IDH3A; OMA:IDH3A - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Isocitrate dehydrogenases (IDHs) catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit. The protein encoded by this gene is the alpha subunit of one isozyme of NAD(+)-dependent isocitrate dehydrogenase. [provided by RefSeq, Jul 2008][6]