Hydroxynorketamine
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Hydroxynorketamine (HNK), or 6-hydroxynorketamine, is a minor metabolite of the anesthetic, dissociative, and antidepressant drug ketamine.[1] It is formed by hydroxylation of the intermediate norketamine, another metabolite of ketamine.[1] As of late 2019, (2R,6R)-HNK is in clinical trials for the treatment of depression.[2]
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Other names | HNK; 6-Hydroxynorketamine; 6-HNK | ||
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Formula | C12H14ClNO2 | ||
Molar mass | 239.70 g·mol−1 | ||
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The major metabolite of ketamine is norketamine (80%).[3] Norketamine is secondarily converted into 4-, 5-, and 6-hydroxynorketamines (15%), mainly HNK (6-hydroxynorketamine).[3] Ketamine is also transformed into hydroxyketamine (5%).[3] As such, bioactivated HNK comprises less than 15% of a dose of ketamine.[3]