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Howell-Jolly body-like inclusions (HJBLi) are a hematopathological finding of an inclusion arising from detached DNA nuclear fragment in white blood cells caused by dysplastic granulopoiesis.[1] The inclusion is aptly named for its similar appearance of the Howell–Jolly body in erythrocytes.[2] The term was coined in 1989.[2]
They are most often observed in neutrophils, but can also appear in monocytes, lymphocytes, eosinophils.[2]
They may appear in patients on immunosuppression and antiviral therapies with nucleoside analogs, anticancer chemotherapeutic agents, active COVID-19 infections, HIV/AIDS, and myelodysplastic syndrome. [3][1]
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