Homology directed repair
Mechanism of DNA repair in cells / From Wikipedia, the free encyclopedia
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Homology-directed repair (HDR) is a mechanism in cells to repair double-strand DNA lesions.[1] The most common form of HDR is homologous recombination. The HDR mechanism can only be used by the cell when there is a homologous piece of DNA present in the nucleus, mostly in G2 and S phase of the cell cycle. Other examples of homology-directed repair include single-strand annealing and breakage-induced replication. When the homologous DNA is absent, another process called non-homologous end joining (NHEJ) takes place instead.[2][3]
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