Hesperadin is an aurora kinase inhibitor.
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Names | |
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Preferred IUPAC name
N-[(3Z)-2-Oxo-3-(phenyl{4-[(piperidin-1-yl)methyl]anilino}methylidene)-2,3-dihydro-1H-indol-5-yl]ethanesulfonamide | |
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CompTox Dashboard (EPA) |
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Properties | |
C29H32N4O3S | |
Molar mass | 516.66 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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The small molecule inhibits chromosome alignment and segregation by limiting the function of mitotic kinases Aurora B and Aurora A. Hesperadin causes cells to enter anaphase much faster, sometimes before the chromosomes are properly bi-oriented.[1]
Hesperadin, like other miotic inhibitors, limits and sometimes can stop the process of mitosis in cells. For this reason, some have considered hesperadin's potential as a cancer-preventing drug.[2]
Hesperadin works as an inhibitor, attaching to the active sites of Aurora A and Aurora B kinases.[2]
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